Salmon J F, Wright J P, Murray A D
Department of Ophthalmology, University of Cape Town, South Africa.
Ophthalmology. 1991 Apr;98(4):480-4. doi: 10.1016/s0161-6420(91)32268-1.
During a 4-year period, the authors examined 19 patients with Crohn's disease and associated ocular inflammation. Seven patients had uveitis, eight had episcleritis, and four had anterior scleritis. Large peripheral corneal infiltrates developed in two patients with scleritis. Increased bowel activity was closely related to the presence of acute episcleritis but not to uveitis or scleritis. To determine risk factors for the development of ocular inflammation, this group of 19 patients was compared with a group of 93 patients with Crohn's disease in whom ocular inflammation was not present. There were no demographic differences between the groups. Patients with colitis or ileocolitis were more likely to suffer from ocular inflammation (23.9%, 17 of 71), than patients with small bowel involvement alone (2.8%, 1 of 36) (P = 0.013). Those with arthritis or arthralgia had a higher incidence of ocular inflammation (29.4%, 15 of 51), than patients without joint involvement (6.6%, 4 of 61) (P = 0.003). These results suggest that the risk of developing ocular inflammation in Crohn's disease may be related to the site of bowel involvement and to the presence of arthritis.
在4年期间，作者检查了19例克罗恩病伴眼部炎症的患者。7例患有葡萄膜炎，8例患有巩膜炎，4例患有前巩膜炎。2例巩膜炎患者出现了大的周边角膜浸润。肠道活动增加与急性巩膜炎的存在密切相关，但与葡萄膜炎或巩膜炎无关。为了确定眼部炎症发生的危险因素，将这19例患者与93例无眼部炎症的克罗恩病患者进行了比较。两组在人口统计学上无差异。患有结肠炎或回结肠炎的患者比仅累及小肠的患者更容易发生眼部炎症（23.9%，71例中的17例）（2.8%，36例中的1例）（P = 0.013）。患有关节炎或关节痛的患者比无关节受累的患者眼部炎症发生率更高（29.4%，51例中的15例）（6.6%，61例中的4例）（P = 0.003）。这些结果表明，克罗恩病患者发生眼部炎症的风险可能与肠道受累部位和关节炎的存在有关。
