Repka M X, Bressler N M, D'Anna S A
Wilmer Ophthalmologic Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Ophthalmology. 1991 Apr;98(4):535-40. doi: 10.1016/s0161-6420(91)32259-0.
Perfluoropropane (C3F8) was injected into nine eyes of six cynomolgus monkeys. In all nine eyes, macular changes consistent with the development of a macular cyst were noted within 3 months after injection. On fluorescein angiography, there was no evidence of retinal vascular leakage associated with the macular cysts. Histopathologic evaluation of six eyes demonstrated microcystic changes throughout the perifoveal inner nuclear layer. These coalesced into larger cystic spaces in the outer plexiform layer of the central macula. These macular changes are previously unreported in patients or monkeys undergoing intravitreal injection of expansile gases. This model for macular cysts may be helpful in evaluating the pathogenesis and role of interventional strategies in patients with cystoid macular edema.
将全氟丙烷（C3F8）注入6只食蟹猴的9只眼中。在所有9只眼中，注射后3个月内均观察到与黄斑囊肿形成一致的黄斑变化。荧光素血管造影显示，黄斑囊肿无视网膜血管渗漏迹象。对6只眼进行组织病理学评估，结果显示整个中心凹周围内核层有微囊性改变。这些微囊在中央黄斑的外丛状层融合成更大的囊腔。这种黄斑变化在接受玻璃体内注射膨胀性气体的患者或猴子中此前未见报道。这种黄斑囊肿模型可能有助于评估黄斑囊样水肿患者的发病机制及介入策略的作用。
