Wallow I H, Danis R P, Bindley C, Neider M
Department of Ophthalmology, University of Wisconsin School of Medicine, Madison.
Ophthalmology. 1988 Oct;95(10):1371-9. doi: 10.1016/s0161-6420(88)33001-0.
Macular edema and collateral vessels were examined clinically and histopathologically up to 48 months after branch retinal vein occlusion in six eyes of five cynomolgus monkeys. In all six, central macular swelling and fluorescein leakage from the retinal vasculature were confined to the acute stage. However, histopathologically, at the chronic stage, only two maculas were completely recovered and unremarkable, whereas the other four showed variable degrees of cystoid degeneration and photoreceptor cell loss. In the two recovered maculas, six to eight normal-sized capillaries separated the fovea from the nearest cluster of capillary collaterals. In three maculas with cystic degeneration, collaterals incorporated the circumfoveal capillaries. In the fourth macula with cystic degeneration, collaterals were separated from the center by two normal-sized capillaries but were also associated with large areas of capillary nonperfusion partially due to occlusion of the macular arteriole.
对5只食蟹猴的6只眼睛进行了视网膜分支静脉阻塞后长达48个月的临床和组织病理学检查，观察黄斑水肿和侧支血管情况。在所有6只眼中，黄斑中心肿胀和视网膜血管荧光素渗漏仅限于急性期。然而，组织病理学检查显示，在慢性期，只有2只眼的黄斑完全恢复且无异常，而另外4只眼则表现出不同程度的囊样变性和光感受器细胞丢失。在2只恢复的黄斑眼中，有6至8根正常大小的毛细血管将中央凹与最近的毛细血管侧支群隔开。在3只有囊样变性的黄斑眼中，侧支血管并入了中央凹周围的毛细血管。在第4只有囊样变性的黄斑眼中，侧支血管与中央被2根正常大小的毛细血管隔开，但也与大面积的毛细血管无灌注有关，部分原因是黄斑小动脉阻塞。
