低流行率的慢性铍病在核武器研究和开发设施的工人中。
Low prevalence of chronic beryllium disease among workers at a nuclear weapons research and development facility.
机构信息
Department of Medicine, University of California, San Francisco, CA, USA.
出版信息
J Occup Environ Med. 2010 Jun;52(6):647-52. doi: 10.1097/JOM.0b013e3181e36439.
OBJECTIVE
To study the prevalence of beryllium sensitization (BeS) and chronic beryllium disease (CBD) in a cohort of workers from a nuclear weapons research and development facility.
METHODS
We evaluated 50 workers with BeS with medical and occupational histories, physical examination, chest imaging with high-resolution computed tomography (N = 49), and pulmonary function testing. Forty of these workers also underwent bronchoscopy for bronchoalveolar lavage and transbronchial biopsies.
RESULTS
The mean duration of employment at the facility was 18 years and the mean latency (from first possible exposure) to time of evaluation was 32 years. Five of the workers had CBD at the time of evaluation (based on histology or high-resolution computed tomography); three others had evidence of probable CBD.
CONCLUSIONS
These workers with BeS, characterized by a long duration of potential Be exposure and a long latency, had a low prevalence of CBD.
目的
研究核武器研发设施中一组工人的铍致敏（BeS）和慢性铍病（CBD）的患病率。
方法
我们评估了 50 名有 BeS 病史的工人，包括医疗和职业史、体检、高分辨率计算机断层扫描（N=49）胸部成像和肺功能测试。其中 40 名工人还接受了支气管镜检查，进行支气管肺泡灌洗和经支气管活检。
结果
这些工人在该设施的平均就业时间为 18 年，从首次可能暴露到评估时间的平均潜伏期为 32 年。评估时，5 名工人患有 CBD（基于组织学或高分辨率计算机断层扫描）；另外 3 名工人有 CBD 的可能证据。
结论
这些工人的 BeS 特征为潜在的 Be 暴露时间长和潜伏期长， CBD 的患病率较低。
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