通过钯（II）催化乙烯基醚向氮亲核试剂的乙烯基转移形成烯酰胺。
Formation of enamides via palladium(II)-catalyzed vinyl transfer from vinyl ethers to nitrogen nucleophiles.
作者信息
Brice Jodie L, Meerdink James E, Stahl Shannon S
机构信息
University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706, USA.
出版信息
Org Lett. 2004 May 27;6(11):1845-8. doi: 10.1021/ol0494360.
PMID:15151429
Abstract
Palladium(II) complexes catalyze the formation of enamides via the formal cross-coupling reaction between nitrogen nucleophiles and vinyl ethers. These vinyl transfer reactions proceed in good yields with amide, carbamate, and sulfonamide nucleophiles, and the optimal catalyst is (DPP)Pd(OCOCF(3))(2) (DPP = 4,7-diphenyl-1,10-phenanthroline). [reaction: see text]
摘要
钯（II）配合物通过氮亲核试剂与乙烯基醚之间的形式交叉偶联反应催化烯酰胺的形成。这些乙烯基转移反应与酰胺、氨基甲酸酯和磺酰胺亲核试剂反应时产率良好，最佳催化剂是（DPP）Pd（OCOCF(3)）(2)（DPP = 4,7-二苯基-1,10-菲咯啉）。[反应：见正文]
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