Lee Woo Jin, Han Seung Seog, Chang Sung Eun, Lee Mi Woo, Choi Jee Ho, Moon Kee Chan, Koh Jai Kyoung
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Ann Dermatol. 2009 Aug;21(3):255-60. doi: 10.5021/ad.2009.21.3.255. Epub 2009 Aug 31.
Acquired bilateral nevus of Ota-like macules (ABNOM) is a dermal pigmented lesion common in individuals of Oriental origin. The Q-switched Nd:YAG laser (QSNYL) has been used successfully to treat a variety of benign, dermal, pigmented lesions, including nevus of Ota lesions. The similarity between ABNOM and nevus of Ota suggested that QSNYL may also be effective in the former.
To determine the efficacy and side-effect profiles of QSNYL treatment of ABNOM in Korean patients.
Of 42 Korean patients with ABNOM, 29 were treated with QSNYL (1,064 nm, 3 mm spot size, fluence 8~9.5 J/cm(2)), for up to 10 sessions each. Clinical photographs were taken before and after treatment. Lesion clearance was graded and complications such as hyperpigmentation, scarring, hypopigmentation, and erythema were assessed.
Of the 29 treated patients, 19 (66%) showed excellent or good results. Of the patients who were treated more than 3 times, 76% showed good to excellent results. Two patients experienced post-laser hyperpigmentation (PLH), which persisted for more than one month, but no patient experienced persistent erythema or hypertrophic scarring.
QSNYL is safe and effective in the treatment of ABNOM in Korean patients. Short-interval repetitive treatment is especially useful in improving therapeutic results and reducing PLH.
获得性双侧太田痣样斑(ABNOM)是一种在东方人种中常见的皮肤色素沉着病变。调Q Nd:YAG激光(QSNYL)已成功用于治疗多种良性皮肤色素沉着病变,包括太田痣病变。ABNOM与太田痣的相似性表明QSNYL对前者可能也有效。
确定QSNYL治疗韩国患者ABNOM的疗效和副作用情况。
42例韩国ABNOM患者中,29例接受QSNYL治疗(波长1064 nm,光斑大小3 mm,能量密度8~9.5 J/cm²),每人最多治疗10次。治疗前后均拍摄临床照片。对病变清除情况进行分级,并评估色素沉着、瘢痕形成、色素减退和红斑等并发症。
29例接受治疗的患者中,19例(66%)显示出优异或良好的效果。治疗次数超过3次的患者中,76%显示出良好至优异的效果。2例患者出现激光后色素沉着(PLH),持续时间超过1个月,但没有患者出现持续性红斑或肥厚性瘢痕。
QSNYL治疗韩国患者的ABNOM安全有效。短间隔重复治疗对提高治疗效果和减少PLH尤其有用。