Department of Plastic and Aesthetic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, P. R. China.
Department of Plastic and Aesthetic Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P. R. China.
Skin Res Technol. 2023 Mar;29(3):e13298. doi: 10.1111/srt.13298.
The therapeutic efficacy of laser treatments for acquired bilateral nevus of Ota-like macules (ABNOM) varies among studies, and few studies have evaluated the factors affecting therapeutic effects.
To evaluate the efficacy and safety of 1064-nm Q-switched Nd:YAG laser (QSNYL) therapy for ABNOM and to identify the factors influencing the outcome.
A total of 110 patients with ABNOM were retrospectively evaluated and received two-to-nine treatment sessions. The effects of different factors on the therapeutic effect were analyzed on the basis of the number of treatments, age at first treatment, skin type, lesion color, affected area, number of lesion sites, and presence of concomitant melasma.
The curative effect was positively correlated with the treatment time and negatively correlated with the increasing age at first treatment (p < 0.05). The curative effect was better in patients with skin type III than those with type IV ( p < 0.05) and in patients with a lesion area of less than 10 cm than those with a larger affected area (p < 0.05). Additionally, the treatment effect was poorer in patients with concomitant melasma (p < 0.05). The treatment effect was not significantly correlated with the lesion color or number of affected sites (p > 0.05). Eleven patients (10%) developed postinflammatory hyperpigmentation (PIH).
Early and repeated QSNYL therapy achieved satisfactory results for ABNOM. The risk of PIH after laser treatment is highest among patients with older age, darker lesion color, and darker skin color. For patients with ABNOM with concurrent melasma, low-energy laser therapy is recommended to reduce the risk of melasma aggravation.
激光治疗获得性双侧太田痣样斑（ABNOM）的疗效在不同研究中存在差异，很少有研究评估影响治疗效果的因素。
评价 1064nm Q 开关 Nd：YAG 激光（QSNYL）治疗 ABNOM 的疗效和安全性，并确定影响疗效的因素。
回顾性评估了 110 例 ABNOM 患者，共接受了 2-9 次治疗。根据治疗次数、首次治疗年龄、皮肤类型、皮损颜色、受累面积、皮损部位数和伴发黄褐斑，分析不同因素对治疗效果的影响。
疗效与治疗时间呈正相关，与首次治疗年龄的增加呈负相关（p<0.05）。与 IV 型皮肤相比，III 型皮肤患者的疗效更好（p<0.05），与较大受累面积的患者相比，皮损面积小于 10cm 的患者疗效更好（p<0.05）。此外，伴发黄褐斑的患者治疗效果较差（p<0.05）。治疗效果与皮损颜色或皮损部位数无显著相关性（p>0.05）。11 例（10%）患者发生炎症后色素沉着过度（PIH）。
早期和重复 QSNYL 治疗对 ABNOM 取得了满意的效果。激光治疗后 PIH 的风险在年龄较大、皮损颜色较深和皮肤颜色较深的患者中最高。对于伴有黄褐斑的 ABNOM 患者，建议采用低能量激光治疗以降低黄褐斑加重的风险。
