Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, Netherlands.
J Mol Med (Berl). 2010 Sep;88(9):881-8. doi: 10.1007/s00109-010-0639-9. Epub 2010 Jun 4.
Although the knowledge of the effects of bacterial colonization on the immune system is rapidly expanding, surprisingly little is known about the immunological mechanisms that shape the intestinal microbial community. Specifically, the complexity of the intestinal microbiota and what constitutes a "healthy" microbial composition has only recently been addressed, facilitated by large-scale metagenomic screens. Containment of such a vast number of different microbes requires tight regulation at the mucosal surface. While beneficial relationships must not be compromised, invading pathogenic bacteria must be dealt with in order to maintain homeostasis. In this review, we will address the latest insights into the role of the mucosal immune system in the control of the microbiota.
尽管人们对细菌定植对免疫系统的影响的了解正在迅速扩展，但对于塑造肠道微生物群落的免疫学机制却知之甚少。具体而言，肠道微生物组的复杂性以及什么构成“健康”的微生物组成，只是最近才通过大规模的宏基因组筛选得以解决。要容纳如此众多不同的微生物，就需要在黏膜表面进行严格的调控。在保持有益关系的同时，还必须应对入侵的病原菌，以维持体内平衡。在这篇综述中，我们将探讨黏膜免疫系统在控制微生物群中的最新见解。
