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药物控释系统中药物释放的动力学建模

Kinetic modeling on drug release from controlled drug delivery systems.

作者信息

Dash Suvakanta, Murthy Padala Narasimha, Nath Lilakanta, Chowdhury Prasanta

机构信息

Girijananda Chowdhury Institute of Pharmaceutical Science, Azara, Hathkhowapara, NH-37, Guwahati, Assam 781 017, India.

出版信息

Acta Pol Pharm. 2010 May-Jun;67(3):217-23.

Abstract

In this paper we review the mathematical models used to determine the kinetics of drug release from drug delivery systems. The quantitative analysis of the values obtained in dissolution/release rates is easier when mathematical formulae are used to describe the process. The mathematical modeling can ultimately help to optimize the design of a therapeutic device to yield information on the efficacy of various release models.

摘要

在本文中,我们回顾了用于确定药物从给药系统释放动力学的数学模型。当使用数学公式来描述溶解/释放速率过程时,对所获得值的定量分析会更容易。数学建模最终有助于优化治疗装置的设计,以获取有关各种释放模型功效的信息。

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