Hariyadi Dewi Melani, Fawwaz Lubby Razan, Fattah Abdul, Rosita Noorma, Purwanti Tutiek, Erawati Tristiana
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia.
Pharmaceutics and Delivery Systems for Drugs, Cosmetics and Nanomedicine (Pharm-DCN) Research Group, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia.
J Adv Pharm Technol Res. 2025 Jul-Sep;16(3):133-138. doi: 10.4103/JAPTR.JAPTR_376_24. Epub 2025 Aug 9.
Some antituberculosis drugs were reported to have adverse effects. The study investigates the use of quercetin pulmospheres as an alternative to traditional antituberculosis drugs. Formulated with alginate and kappa carrageenan as F1, F2, and F3 (1:1, 1:2, and 1:3), the pulmospheres were observed for the release and deposition in rat lungs. Results show a sustained release of 50.47% ±0.43%-58.37% ±0.57% in 10 h above minimum inhibitory concentration (MIC) against and provided Higuchi kinetics model. Pulmospheres delivered quercetin to the lungs and showed a deposition with high concentrations. The slowest rate was occurred in pulmospheres with polymer ratio of 1:2. Formula F2 showed the most optimal results with the lowest rhodamine B concentration of 11.934 ± 2.751-12.364 ± 0.070 µg/g and 6.987 ± 1.931-8.685 ± 2.672 µg/g for left and right lung, respectively, which produced same MIC compare to F1 and F3. The study suggests further evaluation of effective doses for antituberculosis.
据报道，一些抗结核药物有不良反应。本研究调查了槲皮素肺球作为传统抗结核药物替代品的用途。以海藻酸盐和κ-卡拉胶按F1、F2和F3（1:1、1:2和1:3）配方制备的肺球，观察其在大鼠肺部的释放和沉积情况。结果显示，在10小时内，对[具体病菌名称缺失]的最低抑菌浓度（MIC）以上持续释放率为50.47%±0.43%-58.37%±0.57%，并提供了Higuchi动力学模型。肺球将槲皮素输送到肺部，并显示出高浓度沉积。聚合物比例为1:2的肺球释放速率最慢。配方F2显示出最理想的结果，左肺和右肺的罗丹明B浓度最低，分别为11.934±2.751-12.364±0.070μg/g和6.987±1.931-8.685±2.672μg/g，与F1和F3相比产生相同的MIC。该研究建议进一步评估抗结核的有效剂量。
