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一期开放式鼓室成形术:长期疗效及预后因素

Single-stage canal wall-down tympanoplasty: long-term results and prognostic factors.

作者信息

de Zinis Luca Oscar Redaelli, Tonni Daniela, Barezzani Maria Grazia

机构信息

Department of Otorhinolaryngology, University of Brescia, Brescia, Italy.

出版信息

Ann Otol Rhinol Laryngol. 2010 May;119(5):304-12. doi: 10.1177/000348941011900506.

Abstract

OBJECTIVES

We sought to identify factors associated with anatomic and functional results of canal wall-down tympanoplasty.

METHODS

One hundred eighty-nine primary or relapsing cholesteatomas were consecutively operated on by a single surgeon. Cholesteatoma recurrence rates were evaluated. Predictive values of the patient, disease, and surgical characteristics on cholesteatoma recurrence were estimated. The effect of these variables on keratin pearl development, recurrent otorrhea or granulation tissue formation, and hearing function was tested.

RESULTS

The mean follow-up was 8 years (range, 4 to 15 years). The cholesteatoma relapse rate (+/- SE) estimated by the Kaplan-Meier method was 2.1% +/-1.1%. No variables were associated with relapsing disease. The log-rank test showed a significantly higher probability of keratin pearls in male patients (16.7% versus 2.1%; p = 0.001), young patients (less than 16 years; 51.4% versus 6.2%; p = 0.0001), patients with unencapsulated cholesteatomas (19.5% versus 5.3%; p = 0.06), patients with petrous or accessory cellularity invasion (17.9% versus 7.1%; p = 0.02), and patients with overlay myringoplasty (25% versus 7.9%; p = 0.03). Recurrent otorrhea and granulation tissue were associated with homograft temporalis fascia myringoplasty (14.3% versus 3.8%; p = 0.04). The overall postoperative air-bone gap was within 20 dB in 30.7%; it was within 20 dB in 43.9% (47/107) for intact or reconstructed ossicular chains and in 13.4% (11/82) for nonreconstructed, eroded ossicular chains (p = 0.0001). The air-bone gap was within 20 dB in 42.6% (46/108) when the mucosa of the tympanic cavity was normal and in 14.8% (12/81) when there was granulation tissue within the tympanic cavity (p = 0.0001).

CONCLUSIONS

Single-stage canal wall-down tympanoplasty is an appropriate treatment for acquired tympanomastoid cholesteatoma.

摘要

目的

我们试图确定与开放式鼓室成形术的解剖和功能结果相关的因素。

方法

由一名外科医生连续对189例原发性或复发性胆脂瘤进行手术。评估胆脂瘤复发率。估计患者、疾病和手术特征对胆脂瘤复发的预测价值。测试这些变量对角化珠形成、复发性耳漏或肉芽组织形成以及听力功能的影响。

结果

平均随访8年(范围4至15年)。采用Kaplan-Meier法估计的胆脂瘤复发率(±标准误)为2.1%±1.1%。没有变量与复发性疾病相关。对数秩检验显示男性患者(16.7%对2.1%;p = 0.001)、年轻患者(小于16岁;51.4%对6.2%;p = 0.0001)、未包膜胆脂瘤患者(19.5%对5.3%;p = 0.06)、岩部或副细胞受累患者(17.9%对7.1%;p = 0.02)以及采用覆盖式鼓膜成形术的患者(25%对7.9%;p = 0.03)出现角化珠的概率显著更高。复发性耳漏和肉芽组织与颞肌筋膜同种异体鼓膜成形术相关(14.3%对3.8%;p = 0.04)。总体术后气骨导差在20 dB以内的占30.7%;完整或重建听骨链的患者中43.9%(47/107)气骨导差在20 dB以内,未重建、侵蚀性听骨链的患者中13.4%(11/82)气骨导差在20 dB以内(p = 0.0001)。鼓室黏膜正常时气骨导差在20 dB以内的占42.6%(46/108),鼓室内有肉芽组织时气骨导差在20 dB以内的占14.8%(12/81)(p = 0.0001)。

结论

一期开放式鼓室成形术是后天性鼓室乳突胆脂瘤的合适治疗方法。

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