Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea.
J Dermatolog Treat. 2011 Feb;22(1):11-7. doi: 10.3109/09546630903440098. Epub 2010 Jun 5.
Sarcoidosis is a multi-systemic, non-caseating, granulomatous disorder of unknown origin.
The purpose of our investigation was to describe the clinicopathological characteristics of specific lesions of cutaneous sarcoidosis and treatment outcomes in Korean patients.
A retrospective review was made of 31 patients who were diagnosed with sarcoidosis at Severance Hospital, Yonsei University Health System in Korea between 2000 and 2008; these patients were enrolled in this study. The diagnosis of cutaneous sarcoidosis was made in 17 of the patients. They were confirmed by histopathologic examinations. The clinical features were analyzed through review of medical records, and histopathologic and radiologic examinations.
The patients' primary complaints were cutaneous symptoms (51.6%) and respiratory symptoms (32.3%). The most common presentation of cutaneous sarcoidal lesions was the nodule-plaque form (41.2%) and systemic organ involvement was observed in six cases (35.3%). Treatment modalities included steroid, hydroxychloroquine, cyclosporine, topical tacrolimus, and pulsed dye laser. In our series, five patients (30%) achieved complete resolution of the cutaneous lesions and 10 patients (60%) showed partial resolution after corticosteroid treatment. Also, patients without extracutaneous symptoms responded better to corticosteroid treatment compared to patients with systemic involvement.
These data reveal the diversity of clinical and histopathologic findings of cutaneous sarcoidosis in Korea.
结节病是一种多系统、非干酪样肉芽肿性疾病，病因不明。
本研究旨在描述韩国患者皮肤结节病的临床病理特征和治疗结果。
对 2000 年至 2008 年在韩国延世大学健康系统塞弗伦斯医院诊断为结节病的 31 例患者进行回顾性分析，这些患者被纳入本研究。17 例患者被诊断为皮肤结节病，通过组织病理学检查得到确诊。通过病历、组织病理学和影像学检查分析临床特征。
患者的主要主诉是皮肤症状（51.6%）和呼吸系统症状（32.3%）。皮肤结节病最常见的表现形式为结节斑块型（41.2%），6 例患者存在全身器官受累（35.3%）。治疗方法包括皮质类固醇、羟氯喹、环孢素、局部他克莫司和脉冲染料激光。在本系列中，5 例患者（30%）的皮肤病变完全缓解，10 例患者（60%）经皮质类固醇治疗后部分缓解。此外，无皮肤外症状的患者对皮质类固醇治疗的反应优于有全身受累的患者。
这些数据揭示了韩国皮肤结节病临床和组织病理学表现的多样性。
