Vaish Arvind Kumar, Tripathi Anil Kumar, Gupta Lokesh Kumar, Jain Nirdesh, Agarwal Abhishek, Verma Sudhir Kumar
Department of Internal Medicine, CSM Medical University, Lucknow, Uttar Pradesh, India.
BMJ Case Rep. 2011 Sep 4;2011:bcr0620114330. doi: 10.1136/bcr.06.2011.4330.
The DRESS (drug rash, eosinophilia and systemic symptoms) syndrome, is a type of drug hypersensitivity syndrome, is a severe idiosyncratic reaction to several drugs, mainly antiepileptics and antibiotics, which can occasionally produce acute hepatic failure. In this article, the authors report a case of DRESS syndrome with severe exfoliative dermatitis with acute hepatitis associated with intake of leflunomide. Rapid diagnosis with withdrawal of offending agent is crucial for survival of these cases.
药物疹、嗜酸性粒细胞增多和系统症状（DRESS）综合征是药物超敏反应综合征的一种，是对多种药物（主要是抗癫痫药和抗生素）的严重特异质性反应，偶尔可导致急性肝衰竭。在本文中，作者报告了1例因服用来氟米特引发的伴有严重剥脱性皮炎和急性肝炎的DRESS综合征病例。迅速诊断并停用致病药物对于这些病例的存活至关重要。
