在骨关节炎中改变 HIFs。
Shifting HIFs in osteoarthritis.
出版信息
Nat Med. 2010 Jun;16(6):641-4. doi: 10.1038/nm0610-641.
Abstract
There is no cure for osteoarthritis—the most common disease of the joints. By piecing together the molecular events that drive the progression of this debilitating disease, recent studies published in put hypoxia-inducible factor-2α (HIF-2α) in the driver's seat, opening up new avenues for early detection and treatment (pages 678–686 and 687–693).
摘要
对于骨关节炎——最常见的关节疾病，目前尚无治愈方法。通过拼凑出驱动这种使人衰弱的疾病进展的分子事件，最近发表在[期刊名]上的研究将缺氧诱导因子-2α（HIF-2α）置于主导地位，为早期检测和治疗开辟了新的途径（第 678-686 页和第 687-693 页）。
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本文引用的文献
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Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development.HIF-2alpha 在骨骼生长和骨关节炎发展过程中对软骨内骨化的转录调控。
Nat Med. 2010 Jun;16(6):678-86. doi: 10.1038/nm.2146. Epub 2010 May 23.
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Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction.缺氧诱导因子-2α是一种代谢调节因子，可导致骨关节炎软骨破坏。
Nat Med. 2010 Jun;16(6):687-93. doi: 10.1038/nm.2153. Epub 2010 May 23.
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