FOXP1 常见变异与泛发性白癜风有关。
Common variants in FOXP1 are associated with generalized vitiligo.
机构信息
Human Medical Genetics Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.
出版信息
Nat Genet. 2010 Jul;42(7):576-8. doi: 10.1038/ng.602. Epub 2010 Jun 6.
In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of generalized vitiligo with variants at 3p13 encompassing FOXP1 (rs17008723, combined P=1.04x10(-8)) and with variants at 6q27 encompassing CCR6 (rs6902119, combined P=3.94x10(-7)).
在最近一项针对泛发性白癜风的全基因组关联研究中，我们确定了十个已确认的易感位点。通过在两个欧洲血统的复制队列中测试在全基因组研究中显示出提示性关联的其他位点，我们观察到泛发性白癜风与 3p13 上包含 FOXP1 的变体(rs17008723，联合 P=1.04x10(-8))和包含 CCR6 的变体(rs6902119，联合 P=3.94x10(-7))的 6q27 之间存在复制关联。
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