Fisher Omar Z, Peppas Nicholas A
Department of Biomedical Engineering, University of Texas at Austin, 1 University Station C0400, Austin, TX 78712-1062 USA.
Macromolecules. 2009 May 12;42(9):3391-3398. doi: 10.1021/ma801966r.
A novel method for synthesizing nanoscale polymer networks that swell in acidic media is described here using photoinitiated emulsion polymerization. These nanomatrices consist of a crosslinked core of poly[2-(diethylamino)ethyl methacrylate] surface grafted with poly(ethylene glycol) (PDGP) with an average diameter of 50-150 nm. Control over mesh size, surface charge, encapsulation efficiency and in vitro biocompatibility was obtained by varying crosslinking density. The ability to image nanomatrices in their dry state using conventional scanning electron microscopy was made possible by increasing crosslinking density. Theoretical calculations of matrix mesh sizes were supported by the encapsulation of both insulin and colloidal gold 2-5 nm in diameter. The ability to sequester and control the aggregation of an inorganic phase confirmed their use as a nanocomposite matrix material. These networks could be used as imaging agents, drug delivery devices or as components of sensing devices.
本文描述了一种使用光引发乳液聚合合成在酸性介质中溶胀的纳米级聚合物网络的新方法。这些纳米基质由聚[2-(二乙氨基)乙基甲基丙烯酸酯]的交联核组成，表面接枝有聚乙二醇(PDGP)，平均直径为50-150nm。通过改变交联密度，可以控制网孔尺寸、表面电荷、包封效率和体外生物相容性。通过增加交联密度，使得使用传统扫描电子显微镜对干燥状态的纳米基质进行成像成为可能。胰岛素和直径为2-5nm的胶体金的包封支持了基质网孔尺寸的理论计算。隔离和控制无机相聚集的能力证实了它们作为纳米复合基质材料的用途。这些网络可用作成像剂、药物递送装置或传感装置的组件。
