用于一氧化氮电催化传感的金属原卟啉功能化微电极
Metallo Protoporphyrin Functionalized Microelectrodes for Electrocatalytic Sensing of Nitric Oxide.
作者信息
Li Chen-Zhong, Alwarappan Subbiah, Zhang Wenbo, Scafa Nikki, Zhang Xueji
机构信息
Nanobioengineering/Bioelectronics Lab, Department of Biomedical Engineering, Florida International University, Miami, Florida, USA.
出版信息
Am J Biomed Sci. 2009 May 22;1(3):274-282. doi: 10.5099/aj090300274.
Nitric oxide (NO) has been considered as an important bio-regulatory molecule in the physiological process. All the existing methods often employed for NO measurement are mainly indirect and not suitable for in vivo conditions. In this paper, we report a systematic study of electrocatalytic NO reduction by comparing the redox properties of NO at carbon microelectrodes functionalized by Fe, Mn and Co protoporphyrins. The mechanisms of electrocatalytic reduction of NO by different metalloporphyrins have been proposed and compared. In addition, by varying the metallic cores of the metalloporphyrins, NO exhibits voltammograms in which the cathodic peak current occur at different potential. A comparative study on the electrochemical behavior of each of these metalloporphyrin (as a result of varying the metallic core) has been performed and a possible mechanism for the observed behavior is proposed. The results confirmed the potential applicability of using metalloporphyrins modified electrodes for voltammetric NO detection.
一氧化氮（NO）被认为是生理过程中的一种重要生物调节分子。现有的所有常用于测量NO的方法主要都是间接的，且不适用于体内条件。在本文中，我们通过比较Fe、Mn和Co原卟啉功能化的碳微电极上NO的氧化还原特性，对电催化NO还原进行了系统研究。提出并比较了不同金属卟啉电催化还原NO的机理。此外，通过改变金属卟啉的金属核心，NO呈现出阴极峰电流出现在不同电位的伏安图。对这些金属卟啉（由于金属核心不同）各自的电化学行为进行了比较研究，并提出了观察到的行为的可能机制。结果证实了使用金属卟啉修饰电极进行伏安法检测NO的潜在适用性。
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