芘基功能化三唑连接的 2'-脱氧尿苷探针用于单核苷酸多态性（SNP）的区分。
Pyrene-functionalized triazole-linked 2'-deoxyuridines-probes for discrimination of single nucleotide polymorphisms (SNPs).
机构信息
Dept. of Chemistry, Univ. of Idaho, Moscow, ID-83844, USA.
出版信息
Chem Commun (Camb). 2010 Jul 21;46(27):4929-31. doi: 10.1039/c0cc01133a. Epub 2010 Jun 4.
PMID:20526503
Abstract
Oligonucleotides modified with pyrene-functionalized triazole-linked 2'-deoxyuridines display remarkable hybridization-induced increases in fluorescence emission and enable efficient fluorescent discrimination of SNPs via G-specific quenching.
摘要
经芘基功能化三唑键连 2'-脱氧尿苷修饰的寡核苷酸显示出显著的杂交诱导荧光发射增加，并通过 G 特异性猝灭实现 SNP 的高效荧光区分。
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