Zalups R K
Division of Basic Medical Sciences, Mercer University School of Medicine, Macon, Georgia 31207.
Res Commun Chem Pathol Pharmacol. 1991 Apr;72(1):125-8.
Tiron (sodium 4,5-dihydroxybenzene-1,3-disulfonate) was tested as a potential rescue agent for the nephropathy induced by uranyl fluoride (UO2F2) in rats. When uranyl fluoride was administered (i.v.) to male Sprague-Dawley rats at a dose that delivered 250 micrograms U/kg, moderate to severe cellular necrosis occurred in pars recta segments of proximal tubules in the cortex and outer stripe of the outer medulla of the rats' kidneys within four days after treatment. The severity of renal tubular injury was not significantly diminished when rats were given a 10, 100 or 1,000 mg/kg dose of Tiron (i.p.) 30 minutes after the administration of uranyl fluoride. No obvious protection was noted even when the rats were given a 1,000 mg/kg dose of Tiron 15, 30 and 90 minutes after the administration of uranyl fluoride. Therefore, Tiron does not appear to provide rats substantial protection against a dose of uranyl fluoride that induces moderate to severe renal injury.
对钛铁试剂（4,5-二羟基苯-1,3-二磺酸钠）作为大鼠氟化铀酰（UO₂F₂）诱导的肾病潜在救援剂进行了测试。当以250微克铀/千克的剂量给雄性斯普拉格-道利大鼠静脉注射氟化铀酰时，在治疗后四天内，大鼠肾脏皮质和外髓质外带近端小管的直部出现中度至重度细胞坏死。在注射氟化铀酰30分钟后，给大鼠腹腔注射10、100或1000毫克/千克剂量的钛铁试剂，肾小管损伤的严重程度没有明显减轻。即使在注射氟化铀酰15、30和90分钟后给大鼠腹腔注射1000毫克/千克剂量的钛铁试剂，也未观察到明显的保护作用。因此，钛铁试剂似乎不能为大鼠提供实质性保护，使其免受诱导中度至重度肾损伤剂量的氟化铀酰的影响。
