Sanchez D J, Colomina M T, Domingo J L, Corbella J
Laboratory of Toxicology and Environmental Health, School of Medicine, Rovira i Virgili University, San Lorenzo, Spain.
Biol Trace Elem Res. 1999 Sep;69(3):249-59. doi: 10.1007/BF02783877.
Recent studies have shown that oral vanadate (V5+) administration results in behavioral toxicity in rats. The chelating agent Tiron (sodium 4,5-dihydroxybenzene-1,3-disulfonate) is an effective antidote in the removal of vanadium from vanadium-loaded rats. In this study, the protective activity of Tiron on vanadate-induced behavioral toxicity was evaluated in adult rats. Intraperitoneal treatment with Tiron at 235 or 470 mg/kg was initiated after 6 wk of oral sodium metavanadate administration (16 mg/kg/d) and continued for 2 wk. Although vanadate exposure did not result in a significant reduction in the general activity of the animals in an open field, a lower active avoidance acquisition could be observed. However, the vanadate-induced behavioral deficit was reverted by Tiron administration at 470 mg/kg. The present results suggest that Tiron may protect, at least in part, against metavanadate-induced behavioral toxicity.
最近的研究表明，给大鼠口服钒酸盐（V5+）会导致行为毒性。螯合剂钛铁试剂（4,5-二羟基苯-1,3-二磺酸钠）是从钒负荷大鼠体内去除钒的有效解毒剂。在本研究中，评估了钛铁试剂对成年大鼠钒酸盐诱导的行为毒性的保护活性。在口服偏钒酸钠（16mg/kg/d）6周后，开始以235或470mg/kg的剂量腹腔注射钛铁试剂，并持续2周。虽然钒酸盐暴露并未导致动物在旷场中的总体活动显著减少，但可以观察到主动回避习得能力较低。然而，470mg/kg的钛铁试剂给药可逆转钒酸盐诱导的行为缺陷。目前的结果表明，钛铁试剂可能至少部分地保护大鼠免受偏钒酸盐诱导的行为毒性。
