Institute for National Measurement Standards, National Research Council of Canada, Ottawa, Ontario K1A 0R6, Canada.
Med Phys. 2010 May;37(5):2179-93. doi: 10.1118/1.3375895.
Absorbed dose beam quality conversion factors (k(Q) factors) were obtained for 27 different types of ionization chamber. The aim was to obtain objective evidence on the performance of a wide range of chambers currently available, and potentially used for reference dosimetry, and to investigate the accuracy of the k(Q) calculation algorithm used in the TG-51 protocol.
Measurements were made using the 60Co irradiator and Elekta Precise linac facilities at the National Research Council of Canada. The objective was to characterize the chambers over the range of energies applicable to TG-51 and determine whether each chamber met the requirements of a reference-class instrument. Chamber settling, leakage current, ion recombination and polarity, and waterproofing sleeve effects were investigated, and absorbed dose calibration coefficients were obtained for 60Co and 6, 10, and 25 MV photon beams. Only thimble-type chambers were considered in this investigation and were classified into three groups: (i) Reference chambers ("standard" 0.6 cm3 Farmer-type chambers and their derivatives traditionally used for beam output calibration); (ii) scanning chambers (typically 0.1 cm3 volume chambers used for beam commissioning with 3-D scanning phantoms); and (iii) microchambers (very small volume ion chambers (< or = 0.01 cm3) used for small field dosimetry).
As might be expected, 0.6 cm3 thimble chambers showed the most predictable performance and experimental k(Q) factors were obtained with a relative uncertainty of 0.1%. The performance of scanning and microchambers was somewhat variable. Some chambers showed very good behavior but others showed anomalous polarity and recombination corrections that are not fully explained at present. For the well-behaved chambers, agreement between measured and calculated k(Q) factors was within 0.4%; for some chambers, differences of more than 1% were seen that may be related to the recombination/polarity results. Use of such chambers could result in significant errors in the determination of reference dose in the clinic.
Based on the experimental evidence obtained here, specification for a reference-class ionization chamber could be developed that would minimize the error in using a dosimetry protocol with calculated beam quality conversion factors. The experimental k(Q) data obtained here for a wide range of thimble chambers can be used when choosing suitable detectors for reference dosimetry and are intended to be used in the upcoming update/addendum to the AAPM TG-51 dosimetry protocol.
为 27 种不同类型的电离室获得了吸收剂量束质转换系数(k(Q)因子)。目的是为目前可用于参考剂量学的各种室提供性能的客观证据,并研究 TG-51 协议中使用的 k(Q)计算算法的准确性。
使用加拿大国家研究理事会的 60Co 辐照器和 Elekta Precise 直线加速器进行了测量。目的是在适用于 TG-51 的能量范围内对腔室进行特征描述,并确定每个腔室是否符合参考级仪器的要求。研究了腔室沉降、漏电流、离子复合和极性以及防水套的影响,并获得了 60Co 和 6、10 和 25 MV 光子束的吸收剂量校准系数。本研究仅考虑了指状型室,并将其分为三组:(i)参考室(“标准”0.6 cm3 Farmer 型室及其传统上用于束流输出校准的衍生室);(ii)扫描室(通常是用于 3-D 扫描体模的束流调试的 0.1 cm3 体积室);和(iii)微室(体积非常小的离子室(<或=0.01 cm3),用于小场剂量测定)。
正如预期的那样,0.6 cm3 指状室表现出最可预测的性能,并且实验 k(Q) 因子的相对不确定度为 0.1%。扫描室和微室的性能有些变化。一些腔室表现出非常好的行为,但其他腔室表现出反常的极性和复合校正,目前还不完全解释。对于表现良好的腔室,测量和计算的 k(Q) 因子之间的一致性在 0.4%以内;对于一些腔室,观察到超过 1%的差异,这可能与复合/极性结果有关。在临床中使用此类腔室可能会导致参考剂量测定的显著误差。
根据这里获得的实验证据,可以制定参考级电离室的规范,最大限度地减少使用具有计算束质转换系数的剂量学协议的误差。这里为广泛的指状室获得的实验 k(Q) 数据可用于选择适合参考剂量学的合适探测器,并旨在用于即将更新/添加到 AAPM TG-51 剂量学协议中。