Liu Zhang, Nefzi Adel
Torrey Pines Institute for Molecular Studies, Port Saint Lucie, Florida 34987, USA.
J Comb Chem. 2010 Jul 12;12(4):566-70. doi: 10.1021/cc100054u.
Starting with resin-bound glutamic acid, an efficient synthesis of N-substituted pyrrolidinones is described, using the Ugi four-component reaction (U-4CR). The same methodology is employed to produce N-substituted pyrrolidinone tethered N-substituted piperidines.
从树脂结合的谷氨酸开始，描述了一种使用乌吉四组分反应（U-4CR）高效合成N-取代吡咯烷酮的方法。相同的方法用于制备N-取代吡咯烷酮连接的N-取代哌啶。
