Departamento de Biofísica, Universidade Federal of Rio Grande do Sul, Porto Alegre, Brazil.
Free Radic Res. 2010 Aug;44(8):907-12. doi: 10.3109/10715762.2010.489112.
Sleep disordered breathing (SDB) is related to coronary artery disease (CAD), but the mechanisms are uncertain. SDB is characterized by periods of intermittent hypoxia and free radical formation. This study tested the hypothesis that carbonylation can be the link between SDB and CAD. It included 14 cases with CAD and 33 controls with <50% coronary narrowing. CAD cases have higher erythrocyte carbonyl levels than controls (p = 0.012). Positive correlation was observed between apnea-hypopnea index (AHI) and erythrocyte carbonyl concentration (rho = 0.310; p = 0.027). To predict CAD, including as regressors: AHI, erythrocyte carbonyl, gender, age and body mass index, the significant variables in the Poisson multiple regression model were AHI and erythrocytes carbonyl. An increase of 1 pmol/gHb in erythrocyte carbonyl levels increases by 1.8% the risk of CAD and one unit of AHI increases by 3.8% the risk of CAD. The present findings represent the first evidence in humans that SDB may cause CAD through protein carbonylation.
睡眠呼吸紊乱（SDB）与冠状动脉疾病（CAD）有关，但机制尚不确定。SDB 的特征是间歇性缺氧和自由基形成。本研究检验了羰基化作用可能是 SDB 和 CAD 之间联系的假设。它包括 14 例 CAD 病例和 33 例狭窄<50%的对照病例。CAD 病例的红细胞羰基水平高于对照组（p = 0.012）。红细胞羰基浓度与呼吸暂停低通气指数（AHI）之间存在正相关（rho = 0.310；p = 0.027）。为了预测 CAD，包括回归因子：AHI、红细胞羰基、性别、年龄和体重指数，泊松多项回归模型中的显著变量是 AHI 和红细胞羰基。红细胞羰基水平每增加 1 pmol/gHb，CAD 的风险增加 1.8%，AHI 增加一个单位，CAD 的风险增加 3.8%。本研究结果首次在人类中证明 SDB 可能通过蛋白质羰基化作用导致 CAD。
