Matsuno Osamu, Ueno Kiyonobu, Hayama Yoshitomo, Honda Hidehiro, Yamane Hiroyuki, Saeki Yukihiko
Department of Respiratory Disease, Osaka Minami Medical Center, Osaka, Japan.
J Asthma. 2010 May;47(4):486-8. doi: 10.3109/02770901003759444.
Diffuse panbronchiolitis (DPB), an important cause of progressive obstructive lung disease in the Far East, is a distinctive sinobronchial syndrome with characteristic radiologic and histologic features. Asthma is a chronic inflammatory disease characterized by airway narrowing. The major inflammatory cells involved in the pathogenesis of asthma are type 2 helper T (Th2) cells, eosinophils, and mast cells. The authors' patient was diagnosed with DPB and asthma. Although macrolide therapy led to the disappearance of the radiologic abnormalities indicating centrilobular nodular lesions, the respiratory symptoms and pulmonary function worsened. Administration of inhaled corticosteroids improved the respiratory symptoms and pulmonary function. To the authors' knowledge, no case of DPB with asthma has been reported in the English-language literature.
弥漫性泛细支气管炎（DPB）是远东地区进行性阻塞性肺病的一个重要病因，是一种具有独特放射学和组织学特征的鼻窦支气管综合征。哮喘是一种以气道狭窄为特征的慢性炎症性疾病。参与哮喘发病机制的主要炎症细胞是2型辅助性T（Th2）细胞、嗜酸性粒细胞和肥大细胞。本文作者的患者被诊断为DPB和哮喘。尽管大环内酯类药物治疗使提示小叶中心结节性病变的放射学异常消失，但呼吸症状和肺功能却恶化了。吸入性糖皮质激素的使用改善了呼吸症状和肺功能。据作者所知，英文文献中尚未报道过DPB合并哮喘的病例。
