Telethon Institute for Child Health Research, Centre for Child Health Research, Perth, Australia.
BJOG. 2010 Aug;117(9):1139-50. doi: 10.1111/j.1471-0528.2010.02596.x. Epub 2010 May 28.
To examine the association of fetal alcohol exposure during pregnancy with child and adolescent behavioural development.
The Western Australian Pregnancy Cohort (Raine) Study recruited 2900 pregnancies (1989-91) and the 14-year follow up was conducted between 2003 and 2006.
Tertiary obstetric hospital in Perth, Western Australia.
The women in the study provided data at 18 and 34 weeks of gestation on weekly alcohol intake: no drinking, occasional drinking (up to one standard drink per week), light drinking (2-6 standard drinks per week), moderate drinking (7-10 standard drinks per week), and heavy drinking (11 or more standard drinks per week). Methods Longitudinal regression models were used to analyse the effect of prenatal alcohol exposure on Child Behaviour Checklist (CBCL) scores over 14 years, assessed by continuous z-scores and clinical cutoff points, after adjusting for confounders.
Their children were followed up at ages 2, 5, 8, 10 and 14 years. The CBCL was used to measure child behaviour.
Light drinking and moderate drinking in the first 3 months of pregnancy were associated with child CBCL z-scores indicative of positive behaviour over 14 years after adjusting for maternal and sociodemographic characteristics. These changes in z-score indicated a clinically meaningful reduction in total, internalising and externalising behavioural problems across the 14 years of follow up.
Our findings do not implicate light-moderate consumption of alcohol in pregnancy as a risk factor in the epidemiology of child behavioural problems.
研究孕期胎儿酒精暴露与儿童青少年行为发育的关系。
西澳妊娠队列（Raine）研究招募了 2900 例妊娠（1989-1991 年），并于 2003 年至 2006 年进行了 14 年的随访。
西澳大利亚珀斯的三级产科医院。
研究中的女性在妊娠 18 周和 34 周时提供每周饮酒量的数据：不饮酒、偶尔饮酒（每周不超过 1 标准饮酒量）、轻度饮酒（每周 2-6 标准饮酒量）、中度饮酒（每周 7-10 标准饮酒量）和重度饮酒（每周 11 或更多标准饮酒量）。方法：采用纵向回归模型，在调整混杂因素后，分析产前酒精暴露对 14 年期间儿童行为检查表（CBCL）评分的影响，通过连续 z 评分和临床截断点进行分析。
他们的孩子在 2、5、8、10 和 14 岁时进行了随访。CBCL 用于测量儿童行为。
妊娠前 3 个月的轻度和中度饮酒与儿童 CBCL z 评分相关，提示在调整母亲和社会人口统计学特征后，14 年内存在积极行为。z 评分的这些变化表明，在 14 年的随访过程中，总行为、内化和外化行为问题的数量都有临床意义的减少。
我们的研究结果并未表明妊娠期间轻度-中度饮酒是儿童行为问题流行病学的危险因素。
