Central Denmark Region, Regional Psychiatric Services, Herning and Research Unit West Centre for Psychiatric Research, Herning, Denmark.
Scand J Public Health. 2010 Aug;38(6):625-32. doi: 10.1177/1403494810373673. Epub 2010 Jun 7.
The study compensates for the non-response that was observed in a previous study that estimated the frequencies of mental disorders in long-term sickness absence (LSA) (more than eight weeks of continuous sickness absence). In this study, the frequency of any mental disorder was estimated at 48% by a two-phase design and weighted logistic regression. The total non-response rate was 53.6%. This motivated the present study to compensate for non-response by applying adjustment of the weights and by multiple imputation of missing data in the estimation of the frequencies of mental disorders.
The study took place in a Danish population of 120,000 inhabitants. During one year, all 2,414 incident individuals on LSA were identified. By a two-phase design 1,121 individuals were screened in Phase 1. In Phase 2, which was a subsample of Phase 1, 337 individuals participated in a psychiatric diagnostic examination applying Present State Examination as gold standard. The weighted analyses were based on scores of the screening instrument SCL-8AD compiled of SCL-8, SCL-ANX4, and SCL-DEP6 from the Common Mental Disorders Screening Questionnaire. In the present study, the variables sex, age, municipality, and social transfer income variables were used for the adjustment of weights in weighted analyses and in the imputation models.
The frequencies were: any mental disorder 46%-49%, depression 31%-36%, anxiety 13%-15%, and somatoform disorder 8%-9%.
Irrespective of whether compensation for non-response was applied, the frequencies of mental disorders were similar. The variables used for the compensation were of problematic value.
本研究弥补了之前一项研究中观察到的无应答问题，该研究估计了长期病假（LSA，连续病假超过八周）中精神障碍的频率。在这项研究中，通过两阶段设计和加权逻辑回归，任何精神障碍的频率估计为 48%。总无应答率为 53.6%。这促使本研究通过应用权重调整和对缺失数据进行多重插补来补偿无应答，以估计精神障碍的频率。
该研究在丹麦一个拥有 12 万居民的人群中进行。在一年中，确定了所有 2414 名处于 LSA 的新发病例。通过两阶段设计，在第一阶段对 1121 人进行了筛查。在第二阶段（第一阶段的子样本），有 337 人参加了一项使用当前状态检查作为金标准的精神病学诊断检查。加权分析基于共病性精神障碍筛查问卷中的 SCL-8AD 评分编制，该问卷由 SCL-8、SCL-ANX4 和 SCL-DEP6 组成。在本研究中，性别、年龄、市、社会转移收入变量被用于加权分析和插补模型中的权重调整。
频率为：任何精神障碍 46%-49%、抑郁 31%-36%、焦虑 13%-15%和躯体形式障碍 8%-9%。
无论是否应用无应答补偿，精神障碍的频率都相似。用于补偿的变量具有问题价值。
