膳食中某些微量营养素的摄入与胰腺癌风险的关系：一项义大利病例对照研究。

Dietary intake of selected micronutrients and the risk of pancreatic cancer: an Italian case-control study.

机构信息

Department of Epidemiology, Mario Negri Institute for Pharmacological Research, Milan; Department of Occupational Medicine 'Luigi Devoto Work Clinic', Section of Medical Statistics and Biometry 'Giulio A. Maccacaro', University of Milan, Milan.

Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, Aviano (PN), Italy.

出版信息

Ann Oncol. 2011 Jan;22(1):202-206. doi: 10.1093/annonc/mdq302. Epub 2010 Jun 7.

DOI:10.1093/annonc/mdq302

PMID:20530201

Abstract

OBJECTIVE

several studies have shown an inverse relation between vegetable and fruit intake and pancreatic cancer, but no specific beneficial component of such foods has been consistently identified. We considered the role of 15 selected vitamins and carotenoids and 6 minerals on pancreatic cancer risk in an Italian case-control study.

METHODS

subjects were 326 patients with incident pancreatic cancer and 652 controls, admitted to the same hospitals as cases for acute conditions. Micronutrient computation was based on a validated and reproducible food-frequency questionnaire. We estimated the odds ratios (OR) and confidence intervals (CI) using conditional logistic regression models, adjusted for various confounding factors and for energy intake, according to the residual model.

RESULTS

comparing the highest to the lowest quintile of intake, the OR were 0.60 (95% CI 0.36-0.98) for vitamin E, 0.44 (95% CI 0.27-0.73) for vitamin C, 0.56 (95% CI 0.34-0.93) for folate, and 0.57 (95% CI 0.35-0.92) for potassium. No significant inverse associations were observed for α-carotene (OR = 0.69, 95% CI 0.43-1.12), β-carotene (OR = 0.64, 95% CI 0.39-1.06), and β-cryptoxanthin (OR = 0.66, 95% CI 0.39-1.09). No relation was found for other micronutrients considered.

CONCLUSION

our findings support a favorable role of vitamins E and C, selected carotenoids, and folate on pancreatic carcinogenesis.

摘要

目的

多项研究表明蔬菜和水果的摄入与胰腺癌呈负相关，但尚未确定此类食物的具体有益成分。我们在一项义大利的病例对照研究中，研究了 15 种选定的维生素和类胡萝卜素以及 6 种矿物质对胰腺癌风险的作用。

方法

研究对象为 326 名新发胰腺癌患者和 652 名对照者，这些对照者因急性病症被收入与病例相同的医院。微量营养素的计算基于一个经过验证和可重复的食物频率问卷。我们根据残余模型，使用条件逻辑回归模型调整了各种混杂因素和能量摄入，估计了比值比（OR）和置信区间（CI）。

结果

与摄入最低五分位数相比，最高五分位数的 OR 分别为维生素 E 为 0.60（95%CI 0.36-0.98）、维生素 C 为 0.44（95%CI 0.27-0.73）、叶酸为 0.56（95%CI 0.34-0.93）和钾为 0.57（95%CI 0.35-0.92）。α-胡萝卜素（OR=0.69，95%CI 0.43-1.12）、β-胡萝卜素（OR=0.64，95%CI 0.39-1.06）和β-隐黄质（OR=0.66，95%CI 0.39-1.09）无明显负相关关系。其他考虑的微量营养素没有发现相关关系。