意大利一项病例对照研究中类胡萝卜素和视黄醇的膳食摄入量与子宫内膜癌风险

Dietary intake of carotenoids and retinol and endometrial cancer risk in an Italian case-control study.

作者信息

Pelucchi Claudio, Dal Maso Luigino, Montella Maurizio, Parpinel Maria, Negri Eva, Talamini Renato, Giudice Aldo, Franceschi Silvia, La Vecchia Carlo

机构信息

Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.

出版信息

Cancer Causes Control. 2008 Dec;19(10):1209-15. doi: 10.1007/s10552-008-9190-1. Epub 2008 Jul 1.

DOI:10.1007/s10552-008-9190-1

PMID:18592384

Abstract

OBJECTIVES

To provide information on the relation between intake of carotenoids and retinol and endometrial cancer, since available data are inconsistent. Further, carotenoids other than beta-carotene have been rarely investigated.

METHODS

We conducted a multi-centric case-control study in various areas of Italy between 1992 and 2006 on 454 women with incident, histologically confirmed endometrial cancer and 908 controls admitted to the same network of hospitals of cases for acute, non-neoplastic conditions. Intake of carotenoids and retinol was computed from a validated and reproducible food frequency questionnaire. We adjusted for selected covariates, including energy intake, and calculated multivariate odds ratios (OR) and 95% confidence intervals (CI) using conditional logistic regression.

RESULTS

Comparing the highest to the lowest quartile of intake, the ORs of endometrial cancer were 0.69 (95% CI, 0.48-0.99) for beta-carotene, 0.65 (95% CI, 0.45-0.94) for beta-cryptoxanthin, and 0.59 (95% CI, 0.41-0.85) for lutein plus zeaxanthin intake. No association emerged with retinol (OR = 1.31, 95% CI, 0.94-1.84), alpha-carotene (OR = 0.94, 95% CI, 0.66-1.34), and lycopene (OR = 0.95, 95% CI, 0.68-1.34).

CONCLUSIONS

Our results support a favorable role of selected dietary carotenoids on endometrial cancer risk.

摘要

目的

鉴于现有数据存在矛盾，提供有关类胡萝卜素和视黄醇摄入量与子宫内膜癌之间关系的信息。此外，除β-胡萝卜素外的其他类胡萝卜素很少被研究。

方法

1992年至2006年期间，我们在意大利不同地区开展了一项多中心病例对照研究，研究对象为454例经组织学确诊的初发子宫内膜癌女性患者，以及908名因急性非肿瘤性疾病入住与病例相同医院网络的对照者。类胡萝卜素和视黄醇的摄入量通过一份经过验证且可重复的食物频率问卷进行计算。我们对选定的协变量进行了调整，包括能量摄入，并使用条件逻辑回归计算多变量优势比（OR）和95%置信区间（CI）。

结果

将摄入量最高四分位数与最低四分位数进行比较，β-胡萝卜素的子宫内膜癌OR为0.69（95%CI，0.48 - 0.99），β-隐黄质为0.65（95%CI，0.45 - 0.94），叶黄素加玉米黄质摄入量为0.59（95%CI，0.41 - 0.85）。视黄醇（OR = 1.31，95%CI，0.94 - 1.84）、α-胡萝卜素（OR = 0.94，95%CI，0.66 - 1.34）和番茄红素（OR = 0.95，95%CI，0.68 - 1.34）未显示出关联。