Saki Najmaldin, Haybar Habib, Maniati Mahmood, Davari Nader, Javan Mohammadreza, Moghimian-Boroujeni Bahareh
Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Cardiology Department, Medical College, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
J Diabetes Metab Disord. 2024 Aug 9;23(2):1687-1697. doi: 10.1007/s40200-024-01482-8. eCollection 2024 Dec.
Atherosclerosis is an arterial blood vessel disease that begins and progresses by turning macrophages into foam cells. Uptake of oxidized low-density lipoprotein (ox-LDL), cholesterol esterification and cholesterol efflux are the most important factors in the formation of foam cells and play an important role in atherosclerosis.
The present study is based on the data obtained from the PubMed database (1961-2024) using the MeSH search terms "Atherosclerosis", "Macrophages" and "Foam cells". Reviews for writing the main text and non-English-language articles were excluded.
The interaction between ox-LDL and macrophages plays an important role in plaque initiation and promotion processes. Macrophages abnormally digest ox-LDL, resulting in the accumulation of lipids and formation of foam cells. This is an important step in the development of atherosclerosis. Also, several other factors such as inflammatory factors, growth factors, hormones, etc. can play an important role in the development of atherosclerotic lesions or counteract it by affecting the formation of foam cells.
Several factors can affect the progression of atherosclerosis by affecting macrophage activity or its conversion to foam cells. Also, some of these factors play a protective role against the development and atherosclerosis progression. In this paper, we reviewed some of these factors and their effect on atherosclerosis.
动脉粥样硬化是一种动脉血管疾病，其起始和进展过程是巨噬细胞转变为泡沫细胞。氧化型低密度脂蛋白（ox-LDL）的摄取、胆固醇酯化和胆固醇流出是泡沫细胞形成的最重要因素，在动脉粥样硬化中起重要作用。
本研究基于从PubMed数据库（1961 - 2024年）获取的数据，使用医学主题词（MeSH）搜索词“动脉粥样硬化”“巨噬细胞”和“泡沫细胞”。排除用于撰写正文的综述和非英文文章。
ox-LDL与巨噬细胞之间的相互作用在斑块起始和进展过程中起重要作用。巨噬细胞异常摄取ox-LDL，导致脂质积累和泡沫细胞形成。这是动脉粥样硬化发展的重要步骤。此外，其他一些因素，如炎症因子、生长因子、激素等，可在动脉粥样硬化病变发展中起重要作用，或通过影响泡沫细胞形成来对抗动脉粥样硬化。
若干因素可通过影响巨噬细胞活性或其向泡沫细胞的转化来影响动脉粥样硬化的进展。此外，其中一些因素对动脉粥样硬化的发展和进展起保护作用。在本文中，我们综述了其中一些因素及其对动脉粥样硬化的影响。
