Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.
J Cereb Blood Flow Metab. 2010 Aug;30(8):1437-40. doi: 10.1038/jcbfm.2010.77. Epub 2010 Jun 9.
Any tracer in fetal tissue comes from maternal arterial blood. Provided steady state is achieved and intermediate compartments are reversible, the Logan graphical methods should be applicable to the assessment of binding parameters in the fetal brain. Two pregnant rhesus macaques were studied with fallypride and the Logan method was used to assess dopamine receptor distribution volume ratios (DVRs) in both maternal and fetal striatum. The agreement between fetal striatal DVRs using maternal arterial blood and maternal and fetal cerebellum as input functions strongly supports our hypothesis that the conditions necessary for graphical analysis have been met.
胎儿组织中的任何示踪剂都来自母体动脉血。只要达到稳定状态并且中间隔室是可逆的，Logan 图形方法就应该适用于评估胎儿大脑中的结合参数。用 fallypride 研究了两只怀孕的恒河猴，并使用 Logan 方法评估了母体和胎儿纹状体中的多巴胺受体分布容积比（DVR）。使用母体动脉血和母体和胎儿小脑作为输入函数的胎儿纹状体 DVR 之间的一致性强烈支持我们的假设，即已经满足了图形分析所需的条件。
