在德拉敦（北阿坎德邦）一家三级护理医院就诊的患者中获得性抗结核药物耐药性的五年趋势。
Five-year trend of acquired antitubercular drug resistance in patients attending a tertiary care hospital at Dehradun (Uttarakhand).
作者信息
Rawat Jagdish, Sindhwani G, Juyal Ruchi, Dua Ruchi
机构信息
Department of Pulmonary Medicine, Himalayan Institute of Medical Sciences, Swami Rama Nagar, Doiwala, Dehradun (Uttaranchal), India.
出版信息
Lung India. 2009 Oct;26(4):106-8. doi: 10.4103/0970-2113.56342.
Abstract
BACKGROUND/AIM: To study the prevalence and trend of acquired drug resistance to the first line antitubercular drugs.
MATERIALS AND METHODS
Sputum of 215 previously treated adult pulmonary tuberculosis (TB) patients over a period of 2002-2006 were subjected to culture and sensitivity testing against common antitubercular drugs.
RESULT
Growth of Mycobacterium tuberculosis was obtained from sputum specimen of 184 (85.58%) of the 215 patients who were studied; Overall, 113 (62.77%) of these were resistant to at least one antitubercular drug. Resistance to isoniazid was most common (62.22%) followed by rifampicin (57.22%). Multidrug resistance (MDR) was observed in 103 (57.22%) cases. During the five-year study period, an increasing trend in drug resistance including MDR-TB was observed.
CONCLUSION
This study showed increasing trend in drug resistance including MDR-TB in five years.
摘要
背景/目的：研究一线抗结核药物获得性耐药的患病率及趋势。
材料与方法
对2002年至2006年期间215例既往接受过治疗的成年肺结核患者的痰液进行培养，并针对常见抗结核药物进行敏感性检测。
结果
在研究的215例患者中，184例（85.58%）的痰液标本培养出结核分枝杆菌；总体而言，其中113例（62.77%）对至少一种抗结核药物耐药。对异烟肼的耐药最为常见（62.22%），其次是利福平（57.22%）。103例（57.22%）病例观察到耐多药（MDR）情况。在五年的研究期间，观察到包括耐多药结核病在内的耐药性呈上升趋势。
结论
本研究表明，五年内包括耐多药结核病在内的耐药性呈上升趋势。
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