Rawat Jagdish, Sindhwani G, Juyal Ruchi, Dua Ruchi
Department of Pulmonary Medicine, Himalayan Institute of Medical Sciences, Swami Rama Nagar, Doiwala, Dehradun (Uttaranchal), India.
Lung India. 2009 Oct;26(4):106-8. doi: 10.4103/0970-2113.56342.
BACKGROUND/AIM: To study the prevalence and trend of acquired drug resistance to the first line antitubercular drugs.
Sputum of 215 previously treated adult pulmonary tuberculosis (TB) patients over a period of 2002-2006 were subjected to culture and sensitivity testing against common antitubercular drugs.
Growth of Mycobacterium tuberculosis was obtained from sputum specimen of 184 (85.58%) of the 215 patients who were studied; Overall, 113 (62.77%) of these were resistant to at least one antitubercular drug. Resistance to isoniazid was most common (62.22%) followed by rifampicin (57.22%). Multidrug resistance (MDR) was observed in 103 (57.22%) cases. During the five-year study period, an increasing trend in drug resistance including MDR-TB was observed.
This study showed increasing trend in drug resistance including MDR-TB in five years.
背景/目的：研究一线抗结核药物获得性耐药的患病率及趋势。
对2002年至2006年期间215例既往接受过治疗的成年肺结核患者的痰液进行培养，并针对常见抗结核药物进行敏感性检测。
在研究的215例患者中，184例（85.58%）的痰液标本培养出结核分枝杆菌；总体而言，其中113例（62.77%）对至少一种抗结核药物耐药。对异烟肼的耐药最为常见（62.22%），其次是利福平（57.22%）。103例（57.22%）病例观察到耐多药（MDR）情况。在五年的研究期间，观察到包括耐多药结核病在内的耐药性呈上升趋势。
本研究表明，五年内包括耐多药结核病在内的耐药性呈上升趋势。
