Park Sang Hoon, Song Su Jeong
Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, #108 Pyeong-dong, Jongno-gu, Seoul, Korea.
Korean J Ophthalmol. 2010 Jun;24(3):182-5. doi: 10.3341/kjo.2010.24.3.182. Epub 2010 Jun 5.
We report a rare case of multicentric Castleman's disease that presented with ophthalmic involvement, along with a review of the literature. A 63-year-old male presented with decreased visual acuity in both eyes. Both eyes had serous elevations of the retinas with shifting subretinal fluid and annular choroidal detachment. No retinal breaks were found. Laboratory tests revealed pancytopenia, hypergammaglobulinemia, and an increased erythrocyte sedimentation rate. Chest and abdominal computed tomographies showed multiple lymphadenopathies in the mediastinum, abdomen, and in both inguinal areas. Histological examination of the inguinal lymph node biopsy was consistent with Castleman's disease. After combination chemotherapy, the serous elevations of both retinas and the annular choroidal detachments of both eyes disappeared. Ophthalmic involvement in Castleman's disease is very rare, and to the authors' knowledge, this is the first report of ophthalmic involvement of Castleman's disease in Korea.
我们报告一例罕见的多中心性Castleman病伴眼部受累病例，并对相关文献进行综述。一名63岁男性出现双眼视力下降。双眼视网膜有浆液性隆起，伴有视网膜下液移位和环形脉络膜脱离。未发现视网膜裂孔。实验室检查显示全血细胞减少、高球蛋白血症和红细胞沉降率升高。胸部和腹部计算机断层扫描显示纵隔、腹部和双侧腹股沟区有多处淋巴结肿大。腹股沟淋巴结活检的组织学检查结果符合Castleman病。联合化疗后，双眼视网膜的浆液性隆起和环形脉络膜脱离均消失。Castleman病累及眼部非常罕见，据作者所知，这是韩国首例Castleman病累及眼部的报告。
