Snead M P, James J N, Snead D R, Robson D K, Rizk S N
Orbital Clinic, University Hospital, Nottingham, UK.
Eye (Lond). 1993;7 ( Pt 1):84-8. doi: 10.1038/eye.1993.18.
A series of 100 consecutive orbitotomies for tumour was assessed. Lymphoid infiltrations contributed 27% and malignant non-Hodgkin lymphoma was the commonest primary malignant orbital tumour in this series. The clinical and histological features of the first histologically proven case of primary orbital Castleman's disease are reported, as are the results of a study of 27 patients with pure orbital lymphoid infiltrations. The natural history of conjunctival lymphomas differs significantly from that of pure orbital lymphomas and for this reason no conjunctival lymphomas were considered in this series (which therefore contrasts with some previous reports). Histological examination with fresh unfixed tissue available for immunohistochemical staining enhances the diagnostic accuracy of these varied underlying diseases. More than one biopsy may be required before the diagnosis is established. These are significant factors given the differing lines of management for each disorder.
对连续100例因肿瘤而行眶切开术的病例进行了评估。淋巴样浸润占27%，恶性非霍奇金淋巴瘤是该系列中最常见的原发性恶性眼眶肿瘤。本文报告了首例经组织学证实的原发性眼眶Castleman病的临床和组织学特征，以及对27例单纯眼眶淋巴样浸润患者的研究结果。结膜淋巴瘤的自然病程与单纯眼眶淋巴瘤有显著差异，因此本系列未纳入结膜淋巴瘤（这与之前的一些报道不同）。利用新鲜未固定组织进行组织学检查以进行免疫组化染色可提高对这些不同基础疾病的诊断准确性。在确诊之前可能需要多次活检。鉴于每种疾病的治疗方法不同，这些都是重要因素。
