Wagg A S, Lieu P K, Ding Y Y, Malone-Lee J G
Department of Medicine, University College London Medical School, England.
J Urol. 1996 Dec;156(6):1984-8.
The urethral resistance relation was studied in relation to stress incontinence and detrusor instability, and used to examine age related differences in women.
We investigated women with lower urinary tract symptoms and analyzed pressure-flow plot data.
Women with pure detrusor instability had greater detrusor pressures at urethral opening and closure than those with a stable bladder and no stress incontinence. The latter women had greater detrusor opening and closing pressures than those with a stable bladder and genuine stress incontinence at all ages. Detrusor pressures at urethral opening and closure were less in absolute terms in association with greater age. Urethral resistance was lower during voiding in women with stress incontinence.
Our analysis showed a distinct difference in detrusor pressures at urethral opening and closure between women with and without stress incontinence. Differences were also demonstrated between women with and without detrusor instability. We found lower values of these indirect measures of urethral function in association with greater age. There was no evidence of lower urethral compliance in older women with lower urinary tract symptoms.
研究尿道阻力与压力性尿失禁及逼尿肌不稳定的关系，并用于研究女性的年龄相关差异。
我们对有下尿路症状的女性进行了调查，并分析了压力-流率图数据。
单纯逼尿肌不稳定的女性在尿道开放和关闭时的逼尿肌压力高于膀胱稳定且无压力性尿失禁的女性。在所有年龄段，后一组女性的逼尿肌开放和关闭压力均高于膀胱稳定且有真性压力性尿失禁的女性。随着年龄的增长，尿道开放和关闭时的逼尿肌压力绝对值降低。压力性尿失禁女性排尿时的尿道阻力较低。
我们的分析显示，有和没有压力性尿失禁的女性在尿道开放和关闭时的逼尿肌压力存在明显差异。有和没有逼尿肌不稳定的女性之间也表现出差异。我们发现，随着年龄的增长，这些尿道功能间接指标的值较低。没有证据表明有下尿路症状的老年女性尿道顺应性降低。
