Medimate BV, Enschede, The Netherlands.
Lab Chip. 2010 Jul 21;10(14):1799-806. doi: 10.1039/c003899g. Epub 2010 Jun 7.
We present the Medimate Multireader, the first point-of-care lab on a chip device that is based on capillary electrophoresis. It employs disposable pre-filled microfluidic chips with closed electrode reservoirs and a single sample opening. Several technological innovations allow operation with closed reservoirs, which is essential for reliable point-of-care operation. The chips are inserted into a hand-held analyzer. In the present application, the device is used to measure the lithium concentration in blood. Lithium is quantified by conductivity detection after separation from other blood ions. Measurements in patients show good accuracy and precision, and there is no difference between the results obtained by skilled and non-skilled operators. This point-of-care device shows great promise as a platform for the determination of ionic substances in diagnostics or environmental analysis.
我们介绍 Medimate Multireader，这是第一款基于毛细管电泳的即时检测芯片实验室设备。它采用一次性预填充微流控芯片，带有封闭的电极储液器和单个样品入口。多项技术创新允许使用封闭的储液器进行操作，这对于可靠的即时检测操作至关重要。芯片插入手持式分析仪中。在本应用中，该设备用于测量血液中的锂离子浓度。锂离子在与其他血液离子分离后通过电导率检测进行定量。对患者的测量结果显示出良好的准确性和精密度，熟练操作人员和非熟练操作人员的结果之间没有差异。这种即时检测设备作为用于诊断或环境分析中离子物质测定的平台具有广阔的前景。
