Hematology II-Thalassemia, Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy.
J Cell Physiol. 2010 Nov;225(2):385-9. doi: 10.1002/jcp.22269.
The coelomic cavity is part of the extraembryonic mesoderm, surrounding amniotic cavity, embryo, and yolk sac in the early gestation. It is now believed to represent an important transfer interface and a reservoir of nutrients for the embryo. Coelocentesis by ultrasound-guided transvaginal puncture offers an easier access to the early human embryo, from 28 days post-fertilization. However, despite some studies about its biochemical composition being reported, our knowledge about the presence of cellular elements and their quality in this compartment are still limited. Here we studied human coelomic fluids sampled from 6.6 (48 days) to 10 weeks of gestation, demonstrating the presence of functional embryonic erythroid precursors, that is, megaloblasts in the coelomic cavity. The ease of access of the coelomic cavity could allow the development of novel strategies for diagnostic or therapeutic purposes by ultrasound imaging and ultrasound-guided puncture.
体腔是胚外中胚层的一部分，在妊娠早期围绕着羊膜腔、胚胎和卵黄囊。现在人们认为它代表了一个重要的物质交换界面和胚胎营养物质的储存库。经阴道超声引导下的体腔穿刺为获取受精后 28 天的早期人类胚胎提供了更简单的途径。然而，尽管已经有一些关于其生化成分的研究报告，但我们对该腔室中细胞成分的存在及其质量的了解仍然有限。在这里，我们研究了从受精后 6.6 天（48 天）到 10 周龄的人胚体腔液，证明了胚体腔中存在有功能的胚胎红系前体，即巨核细胞。胚体腔的易于接近可以通过超声成像和超声引导下的穿刺为诊断或治疗目的开发新的策略。
