Department of Dermatology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan.
Int J Dermatol. 2010 May;49(5):579-84. doi: 10.1111/j.1365-4632.2010.04384.x.
Chronic idiopathic urticaria (CIU) is often resistant to common treatment of uriticaria.
To find out clinical and laboratory findings affecting the response of oral cyclosporine therapy in CIU.
The response of oral cyclosporine therapy in 15 patients with CIU (male:female = 5:10, age 16-60 years old, mean 40.0 years old) was studied. Cyclosporine trough level was measured with an enzyme-multiplied immunoassay, and high sensitivity-CRP was measured with a nephelometric assay. The relation between high sensitivity-CRP level and clinical and laboratory findings in CIU was also studied.
All the 15 CIU patients responded to oral cyclosporine therapy. High sensitivity-CRP levels before the start of therapy were elevated in nine of 15 CIU patients. The distributions of treatment duration and basophile leukocytes counts in elevated high sensitivity-CRP patients (8.7 +/- 1.3 months, 0.20 +/- 0.05%) were significantly shorter and elevated than those in patients showing no elevation (22.7 +/- 1.7 months, 0.40 +/- 0.05%) (P < 0.05, P < 0.05), respectively. No other clinical and laboratory findings between patients with elevated and not elevated high sensitivity-CRP showed any significant differences.
Chronic idiopathic urticaria patients with elevated high sensitivity-CRP showed good response to oral cyclosporine therapy.
慢性特发性荨麻疹（CIU）通常对荨麻疹的常规治疗有抗性。
找出影响 CIU 口服环孢素治疗反应的临床和实验室发现。
研究了 15 例 CIU 患者（男：女= 5：10，年龄 16-60 岁，平均 40.0 岁）口服环孢素治疗的反应。用酶联免疫吸附法测定环孢素谷浓度，用散射比浊法测定高敏-CRP。还研究了高敏-CRP 水平与 CIU 临床和实验室发现之间的关系。
15 例 CIU 患者均对口服环孢素治疗有反应。15 例 CIU 患者中有 9 例在开始治疗前高敏-CRP 水平升高。高敏-CRP 升高患者的治疗持续时间和嗜碱性粒细胞计数分布（8.7 ± 1.3 个月，0.20 ± 0.05%）明显短于未升高患者（22.7 ± 1.7 个月，0.40 ± 0.05%）（P < 0.05，P < 0.05）。高敏-CRP 升高和未升高患者之间的其他临床和实验室发现无显著差异。
高敏-CRP 升高的慢性特发性荨麻疹患者对口服环孢素治疗反应良好。
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