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1
Reverse biological engineering of hrdB to enhance the production of avermectins in an industrial strain of Streptomyces avermitilis.
Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11250-4. doi: 10.1073/pnas.1006085107. Epub 2010 Jun 7.
2
Inactivation of the extracytoplasmic function sigma factor Sig6 stimulates avermectin production in Streptomyces avermitilis.
Biotechnol Lett. 2011 Oct;33(10):1955-61. doi: 10.1007/s10529-011-0673-x. Epub 2011 Jun 21.
3
Characterization of a regulatory gene, aveR, for the biosynthesis of avermectin in Streptomyces avermitilis.
Appl Microbiol Biotechnol. 2009 Apr;82(6):1089-96. doi: 10.1007/s00253-008-1850-2. Epub 2009 Jan 16.
5
Overexpression of the ABC transporter AvtAB increases avermectin production in Streptomyces avermitilis.
Appl Microbiol Biotechnol. 2011 Oct;92(2):337-45. doi: 10.1007/s00253-011-3439-4. Epub 2011 Jun 29.
7
A novel TetR family transcriptional regulator, SAV576, negatively controls avermectin biosynthesis in Streptomyces avermitilis.
PLoS One. 2013 Aug 13;8(8):e71330. doi: 10.1371/journal.pone.0071330. eCollection 2013.
9
Overexpression of ribosome recycling factor causes increased production of avermectin in Streptomyces avermitilis strains.
J Ind Microbiol Biotechnol. 2010 Jul;37(7):673-9. doi: 10.1007/s10295-010-0710-0. Epub 2010 Mar 30.
10
An extracytoplasmic function sigma factor, σ(25), differentially regulates avermectin and oligomycin biosynthesis in Streptomyces avermitilis.
Appl Microbiol Biotechnol. 2014 Aug;98(16):7097-112. doi: 10.1007/s00253-014-5759-7. Epub 2014 May 9.

引用本文的文献

1
Molecular basis of Streptomyces ECF σShbA factors transcribing principal σHrdB genes.
Nucleic Acids Res. 2025 Apr 22;53(8). doi: 10.1093/nar/gkaf339.
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Applications of synthetic biology in medical and pharmaceutical fields.
Signal Transduct Target Ther. 2023 May 11;8(1):199. doi: 10.1038/s41392-023-01440-5.
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Rethinking Biosynthesis of Aclacinomycin A.
Molecules. 2023 Mar 18;28(6):2761. doi: 10.3390/molecules28062761.
8
CRISPR/Cas9-Mediated Multi-Locus Promoter Engineering in Cluster to Improve Erythromycin Production in .
Microorganisms. 2023 Feb 28;11(3):623. doi: 10.3390/microorganisms11030623.
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Activating cryptic biosynthetic gene cluster through a CRISPR-Cas12a-mediated direct cloning approach.
Nucleic Acids Res. 2022 Apr 8;50(6):3581-3592. doi: 10.1093/nar/gkac181.
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Zinc-Responsive Regulator Zur Regulates Zinc Homeostasis, Secondary Metabolism, and Morphological Differentiation in Streptomyces avermitilis.
Appl Environ Microbiol. 2022 Apr 12;88(7):e0027822. doi: 10.1128/aem.00278-22. Epub 2022 Mar 24.

本文引用的文献

1
Identification of avermectin-high-producing strains by high-throughput screening methods.
Appl Microbiol Biotechnol. 2010 Jan;85(4):1219-25. doi: 10.1007/s00253-009-2345-5. Epub 2009 Dec 2.
3
Medium optimization for the production of avermectin B1a by Streptomyces avermitilis 14-12A using response surface methodology.
Bioresour Technol. 2009 Sep;100(17):4012-6. doi: 10.1016/j.biortech.2009.03.013. Epub 2009 Apr 7.
4
Characterization of a regulatory gene, aveR, for the biosynthesis of avermectin in Streptomyces avermitilis.
Appl Microbiol Biotechnol. 2009 Apr;82(6):1089-96. doi: 10.1007/s00253-008-1850-2. Epub 2009 Jan 16.
8
Systems biology of antibiotic production by microorganisms.
Nat Prod Rep. 2007 Dec;24(6):1262-87. doi: 10.1039/b617765b. Epub 2007 May 30.
10
Global transcription machinery engineering: a new approach for improving cellular phenotype.
Metab Eng. 2007 May;9(3):258-67. doi: 10.1016/j.ymben.2006.12.002. Epub 2007 Jan 8.

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