Department of Epidemiology, University Medical Center Groningen, Hanzeplein 1, PO Box 30.001, 9700 RB Groningen, the Netherlands.
J Clin Endocrinol Metab. 2010 Sep;95(9):E26-31. doi: 10.1210/jc.2010-0305. Epub 2010 Jun 9.
Procalcitonin, a well-known biomarker of sepsis and bacterial infections, is produced by adipose tissue and has potential as a marker for chronic low-grade inflammation.
The objective of this study was to investigate whether plasma procalcitonin levels in the normal range are associated with obesity, insulin resistance, and metabolic syndrome (MS) in the general population.
Plasma procalcitonin (0.006-0.1 ng/ml) was measured in 3197 men and 3638 women (aged 28-75 yr) of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study using an ultrasensitive immunoluminometric assay. MS was defined according to Adult Treatment Panel III criteria.
Median (interquartile range) plasma procalcitonin was 0.018 (0.015-0.022) ng/ml in men and 0.014 (0.012-0.017) ng/ml in women (P < 0.001). Plasma procalcitonin was positively associated with body mass index and waist circumference. In both sexes, cross-sectional associations of plasma procalcitonin with insulin resistance and components of the MS remained significant after adjustment for age, body mass index, waist circumference, and other covariates. The age-adjusted odds ratio (OR) for MS was 3.2 [95% confidence interval (CI) = 2.5-4.2) in men and 4.1 (95% CI = 3.0-5.5) in women, when comparing the highest with the lowest quartile of plasma procalcitonin. The multivariate-adjusted OR for MS was 1.9 (95% CI = 1.4-2.6) in men and 2.3 (95% CI = 1.6-3.3) in women. The multivariate-adjusted OR for insulin resistance was 3.3 (95% CI = 2.4-4.3) in men and 2.5 (95% CI = 1.9-3.4) in women.
Elevated plasma procalcitonin levels in the normal range are associated with measures of obesity, insulin resistance, and MS in the general population.
降钙素原是一种广为人知的败血症和细菌感染生物标志物，由脂肪组织产生，并且可能成为慢性低度炎症的标志物。
本研究旨在调查在普通人群中，正常范围内的血浆降钙素原水平是否与肥胖、胰岛素抵抗和代谢综合征（MS）相关。
采用超敏免疫发光法检测 3197 名男性和 3638 名女性（年龄 28-75 岁）的血浆降钙素原（0.006-0.1ng/ml）。MS 根据成人治疗小组 III 标准定义。
男性和女性的中位（四分位间距）血浆降钙素原分别为 0.018（0.015-0.022）ng/ml 和 0.014（0.012-0.017）ng/ml（P＜0.001）。血浆降钙素原与体重指数和腰围呈正相关。在两性中，在调整年龄、体重指数、腰围和其他协变量后，血浆降钙素原与胰岛素抵抗和 MS 各成分的横断面相关性仍然显著。与最低四分位相比，最高四分位的 MS 的年龄调整比值比（OR）分别为男性 3.2（95%可信区间（CI）=2.5-4.2）和女性 4.1（95%CI=3.0-5.5）。MS 的多变量调整 OR 分别为男性 1.9（95%CI=1.4-2.6）和女性 2.3（95%CI=1.6-3.3）。MS 的多变量调整 OR 分别为男性 3.3（95%CI=2.4-4.3）和女性 2.5（95%CI=1.9-3.4）。
在普通人群中，正常范围内的血浆降钙素原水平升高与肥胖、胰岛素抵抗和 MS 的指标相关。
