Yoshikawa Keiji, Yamada Hiroshi
Yoshikawa Eye Clinic, Tokyo, Japan.
Clin Ophthalmol. 2010 May 25;4:481-6. doi: 10.2147/opth.s10804.
To investigate the influence of container structures and content solutions on the time of dispensing from eye dropper bottles.
Eye dropper bottle models, solution models (filtrate water/surfactant solution) and a dispensing time measuring apparatus were prepared to measure the dispensing time.
With filtrate water and pressure thrust load of 0.3 MPa, the dispensing time significantly increased from 1.1 +/- 0.5 seconds to 4.6 +/- 1.1 seconds depending on the decrease of inner aperture diameters from 0.4 mm to 0.2 mm (P < 0.0001). When using the bottle models with inner aperture diameters of 0.4 mm or larger, the dispensing time became constant. The dispensing time using surfactant solution showed the same tendency as above. When pressure thrust load was large (0.07 MPa), the solution flew out continuously with inner aperture diameters of 0.4 mm or larger and the dispensing time could not be measured. The inner aperture diameter most strongly explained the variation of the dispensing time in both the content solutions in the multiple linear regression analysis (filtrate water: 46%, R(2) = 0.462, surfactant solution: 56%, R(2) = 0.563).
Among content solutions and container structures, the dispensing time was mostly influenced by the diameter of the inner aperture of bottles.
研究容器结构和内容溶液对滴管瓶滴出时间的影响。
准备滴管瓶模型、溶液模型（过滤水/表面活性剂溶液）和滴出时间测量装置来测量滴出时间。
对于过滤水且压力推力负荷为0.3MPa时，随着内孔径从0.4mm减小到0.2mm，滴出时间从1.1±0.5秒显著增加到4.6±1.1秒（P<0.0001）。当使用内孔径为0.4mm或更大的瓶模型时，滴出时间变得恒定。使用表面活性剂溶液时的滴出时间显示出与上述相同的趋势。当压力推力负荷较大（0.07MPa）时，对于内孔径为0.4mm或更大的情况，溶液持续流出且无法测量滴出时间。在多元线性回归分析中，内孔径对两种内容溶液的滴出时间变化解释力最强（过滤水：46%，R² = 0.462；表面活性剂溶液：56%，R² = 0.563）。
在内容溶液和容器结构中，滴出时间主要受瓶内孔径的影响。
