对氧磷酶：其在慢性肾衰竭中的抗动脉粥样硬化作用。
Paraoxonase: Its antiatherogenic role in chronic renal failure.
作者信息
Prakash M, Phani N M, Kavya R, Supriya M
机构信息
Department of Biochemistry, Kasturba Medical College, Manipal - 576 104, India.
出版信息
Indian J Nephrol. 2010 Jan;20(1):9-14. doi: 10.4103/0971-4065.62088.
Paraoxonase (PON) is an aryldialkylphosphatase, which reversibly binds and hydrolyzes organophosphates. The PON family has three members (PON1, PON2 and PON3); they share structural properties and enzymatic activities. PON1 is shown to reside over high density lipoprotein (HDL) and has both antioxidant and antiatherogenic functions. Function of PON2 and PON3 are speculative and still under research. Several methodologies were developed over the years to determine the activity and mass of PON1, of which spectrophotometer-based methods using certain chemicals as substrate predominate. Several studies have shown decreased levels of PON1 in chronic renal failure (CRF) patients, particularly those on hemodialysis. The role of PON1 in development of cardiovascular disease has drawn considerable attention in recent years. Several authors have shown decreased levels of HDL and PON1 activity in CRF patients on hemodialysis and reported this to be a risk factor in the development of CVD. Enhancement or maintenance of the PON1 activity may prevent development of CVDs and its consequences in patients on hemodialysis.
对氧磷酶（PON）是一种芳基二烷基磷酸酶，可与有机磷酸酯可逆结合并使其水解。PON家族有三个成员（PON1、PON2和PON3）；它们具有共同的结构特性和酶活性。已证明PON1存在于高密度脂蛋白（HDL）上，具有抗氧化和抗动脉粥样硬化功能。PON2和PON3的功能尚在推测和研究中。多年来已开发出多种方法来测定PON1的活性和含量，其中以某些化学物质为底物的基于分光光度计的方法占主导地位。多项研究表明，慢性肾衰竭（CRF）患者，尤其是接受血液透析的患者，其PON1水平降低。近年来，PON1在心血管疾病发展中的作用备受关注。几位作者表明，接受血液透析的CRF患者的HDL水平和PON1活性降低，并报告这是心血管疾病发展的一个危险因素。提高或维持PON1活性可能会预防血液透析患者心血管疾病的发生及其后果。
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