终末期肾病患儿髓过氧化物酶与血浆致动脉粥样硬化指数的关联
Association of Myeloperoxidase and the Atherogenic Index of Plasma in Children with End-Stage Renal Disease.
作者信息
Ristovski-Kornic Danijela, Stefanović Aleksandra, Kotur-Stevuljević Jelena, Zeljković Aleksandra, Spasojević-Kalimanovska Vesna, Vekić Jelena, Miljković Milica, Paripović Dušan, Peco-Antić Amira, Jelić-Ivanović Zorana
机构信息
Health Center Pančevo, Serbia.
Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
出版信息
J Med Biochem. 2017 Jan 25;36(1):23-31. doi: 10.1515/jomb-2016-0027. eCollection 2017 Jan.
BACKGROUND
The aim of this study was to explore oxidative stress status, especially the enzyme myeloperoxidase in children with end-stage renal disease. Also, we investigated possible associations between the atherogenic index of plasma and these parameters.
METHODS
Lipid status parameters, oxidative stress status parameters, and myeloperoxidase concentration were measured in the sera of 20 children in the last stage of chronic renal disease (ESRD) and 35 healthy children of matching age and sex. The Atherogenic Index of Plasma (AIP) was calculated according to the appropriate equation.
RESULTS
We did not find any significant differences in myeloperoxidase concentrations between the investigated groups (p=0.394). Oxidative stress parameters were, however, significantly higher in the patient group (p<0.001), as well as the atherogenic index of plasma (p<0.001). Myeloperoxidase concentration and advanced oxidation protein product (AOPP) concentration were independently associated with increased AIP in the patient group (p<0.05).
CONCLUSIONS
Changes in AIP in children with ERSD are associated with the oxidative stress status and myeloper-oxidase concentration.
背景
本研究旨在探讨终末期肾病患儿的氧化应激状态，尤其是髓过氧化物酶。此外，我们还研究了血浆致动脉粥样硬化指数与这些参数之间可能存在的关联。
方法
对20名慢性肾病终末期（ESRD）患儿和35名年龄及性别匹配的健康儿童的血清进行脂质状态参数、氧化应激状态参数和髓过氧化物酶浓度的检测。根据适当公式计算血浆致动脉粥样硬化指数（AIP）。
结果
我们发现研究组之间髓过氧化物酶浓度无显著差异（p = 0.394）。然而，患者组的氧化应激参数以及血浆致动脉粥样硬化指数显著更高（p < 0.001）。患者组中髓过氧化物酶浓度和晚期氧化蛋白产物（AOPP）浓度与AIP升高独立相关（p < 0.05）。
结论
ESRD患儿的AIP变化与氧化应激状态和髓过氧化物酶浓度有关。
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