血液透析患儿的氧化应激
Oxidative Stress in Hemodialysis Pediatric Patients.
作者信息
Shouman Mohamed G, Sabry Samar, Galal Rasha E E, Salama Emad, Wahby Aliaa Ahmed, Awadallah Eman, Selim Abeer
机构信息
Pediatrics Department, Medical Research Division and Medical Research Centre of Excellence (MRCE), National Research Centre, Cairo, Egypt.
Pediatrics Department, Pediatric Nephrology Unit, Cairo University, Cairo, Egypt.
出版信息
Open Access Maced J Med Sci. 2019 Dec 10;7(23):3955-3959. doi: 10.3889/oamjms.2019.859. eCollection 2019 Dec 15.
BACKGROUND
Oxidative stress may play a role in complications of hemodialysis patients as atherosclerosis, thrombosis, and inflammation.
AIM
The aim of the study was to evaluate the oxidative stress in hemodialysis pediatric patients through measurement of oxidative stress enzymes as paraoxanase activity (PON), arylesterase activity (ASA), superoxide dismutase (SOD) and also non-enzymatic antioxidant vitamins as vitamins A, C and E levels.
METHODS
The study included 50 hemodialysis pediatric patients with mean age 11.4 ± 5.4 years and 30 normal children of matched sex and age as a control group. Assessment of oxidative stresses was done using ELIZA technique.
RESULTS
SOD, ASA, and vitamin C were significantly lower among hemodialysis patients in comparison to control group (p = 0.004, 0.004, > 0.001 respectively).
CONCLUSION
The study concluded that oxidative stress was common finding in hemodialysis pediatric patients which may play a role in complications encountered among these patients.
背景
氧化应激可能在血液透析患者的并发症中起作用，如动脉粥样硬化、血栓形成和炎症。
目的
本研究的目的是通过测量氧化应激酶如对氧磷酶活性（PON）、芳基酯酶活性（ASA）、超氧化物歧化酶（SOD）以及非酶抗氧化维生素如维生素A、C和E水平，评估血液透析儿科患者的氧化应激情况。
方法
该研究纳入了50名平均年龄为11.4±5.4岁的血液透析儿科患者，并选取30名年龄和性别匹配的正常儿童作为对照组。使用酶联免疫吸附测定（ELISA）技术评估氧化应激。
结果
与对照组相比，血液透析患者的超氧化物歧化酶（SOD）、芳基酯酶（ASA）和维生素C显著降低（分别为p = 0.004、0.004、> 0.001）。
结论
该研究得出结论，氧化应激在血液透析儿科患者中是常见现象，可能在这些患者所遇到的并发症中起作用。
Zotero 插件