Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea.
J Neurogastroenterol Motil. 2010 Jan;16(1):77-82. doi: 10.5056/jnm.2010.16.1.77. Epub 2010 Jan 31.
Cyclic vomiting syndrome (CVS) is a disorder characterized by recurrent episodes of incapacitating nausea and vomiting interspersed with symptom free periods. Common triggers of cyclic vomiting include noxious stress, excitement, fatigue and menstrual period. Here, we report a case of cyclic vomiting syndrome in adult patient characterized by stereotypical vomiting attack, occurring in every menstruation period. Recurrent vomiting episodes began 6 years ago and we treated this patient with subcutaneous injection of goserelin, a gonadotropin-releasing hormone analogue (GnRHa) and oral estrogen. After 4 months of therapy, she was symptom free for the following 5 years, even with the resumed normal menstruation. Recurrence of vomiting attack with same pattern occurred 1 month before readmission. Treatment with intravenous lorazepam aborted vomiting, but could not prevent recurrences of vomiting and epigastric pain. We treated the patient with GnRHa and oral estradiol again which effectively prevented recurrence of the symptoms.
周期性呕吐综合征（CVS）是一种以反复发作的使人虚弱的恶心和呕吐为特征的疾病，其间穿插着无症状期。周期性呕吐的常见诱因包括有害的应激、兴奋、疲劳和月经期。在这里，我们报告了一例成人周期性呕吐综合征的病例，其特征是刻板的呕吐发作，发生在每个月经期。复发性呕吐发作始于 6 年前，我们用促性腺激素释放激素类似物（GnRHa）戈舍瑞林皮下注射和口服雌激素治疗该患者。经过 4 个月的治疗，她在接下来的 5 年内没有出现症状，即使恢复了正常的月经。在再次入院前 1 个月，出现了同样模式的呕吐发作复发。静脉注射劳拉西泮可以终止呕吐，但不能预防呕吐和上腹痛的复发。我们再次用 GnRHa 和口服雌二醇治疗该患者，有效地预防了症状的再次发作。
