两种不同七氟醚制剂在猪体内的最低肺泡浓度和血液动力学效应。
Minimum alveolar concentrations and hemodynamic effects of two different preparations of sevoflurane in pigs.
机构信息
Laboratory of Medical Investigation, LIM/08 Anesthesiology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
出版信息
Clinics (Sao Paulo). 2010 May;65(5):531-7. doi: 10.1590/S1807-59322010000500011.
BACKGROUND
Original sevoflurane (Sevo A) is made with water, while a generic sevoflurane (Sevocris) is produced with propylene glycol as a stabilizing additive. We investigated whether the original and generic sevoflurane preparations differed in terms of their minimum alveolar concentration (MAC) values and hemodynamic effects.
METHODS
Sixteen pigs weighing 31.6+/-1.8 kg were randomly assigned to the Sevo A or Sevocris groups. After anesthesia induction via mask with the appropriate sevoflurane preparation (6% in 100% oxygen), the MAC was determined for each animal. Hemodynamic and oxygenation parameters were measured at 0.5 MAC, 1 MAC and 1.5 MAC. Histopathological analyses of lung parenchyma were performed.
RESULTS
The MAC in the Sevo A group was 4.4+/-0.5%, and the MAC in the Sevocris group was 4.1+/-0.7%. Hemodynamic and metabolic parameters presented significant differences in a dose-dependent pattern as expected, but they did not differ between groups. Cardiac indices and arterial pressures decreased in both groups when the sevoflurane concentration increased from 0.5 to 1 and 1.5 MAC. The oxygen delivery index (DO(2)I) decreased significantly at 1.5 MAC.
CONCLUSION
Propylene glycol as an additive for sevoflurane seems to be as safe as a water additive, at least in terms of hemodynamic and pulmonary effects.
背景
原有的七氟醚（Sevo A）是用水制成的，而一种通用的七氟醚（Sevocris）则是用丙二醇作为稳定剂制成的。我们研究了原始的和通用的七氟醚制剂在最低肺泡浓度（MAC）值和血液动力学效应方面是否存在差异。
方法
16 头体重为 31.6±1.8kg 的猪被随机分为 Sevo A 或 Sevocris 组。通过面罩吸入适当浓度的七氟醚（6%的 100%氧气）进行麻醉诱导后，确定每个动物的 MAC 值。在 0.5 MAC、1 MAC 和 1.5 MAC 时测量血液动力学和氧合参数。对肺实质进行组织病理学分析。
结果
Sevo A 组的 MAC 值为 4.4±0.5%，Sevocris 组的 MAC 值为 4.1±0.7%。如预期的那样，血液动力学和代谢参数呈剂量依赖性显著差异，但两组之间没有差异。当七氟醚浓度从 0.5 MAC 增加到 1 MAC 和 1.5 MAC 时，两组的心脏指数和动脉压均降低。在 1.5 MAC 时，氧输送指数（DO2I）显著下降。
结论
丙二醇作为七氟醚的添加剂似乎与水添加剂一样安全，至少在血液动力学和肺效应方面是如此。
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