Bukoski R D, Kremer D
Department of Medicine, Oregon Health Sciences University, Portland 97201.
Am J Clin Nutr. 1991 Jul;54(1 Suppl):220S-226S. doi: 10.1093/ajcn/54.1.220S.
The vascular and potentially hypertensive actions of the calcium-regulating hormones 1,25-dihydroxychole-calciferol [1,25(OH)2D3], parathyroid hormone (PTH), and calcitonin and related factors such as parathyroid hypertensive factor (PHF) and calcitonin gene-related peptide (CGRP) are discussed. 1,25(OH)2D3 has inotropic and calciotropic actions on isolated vascular tissue whereas PTH is a vasodilator. PHF, which has been reported in plasma of humans with essential hypertension and spontaneously hypertensive rats, has both pressor and calciotropic actions. Calcitonin is without vascular effects and CGRP is a potent vasodilator. It is concluded that several of the hormones responsible for maintaining Ca2+ homeostasis modulate vascular Ca2+ metabolism and force generating capacity. These substances may be long-term modulators of vascular function and play a role in the determination of peripheral vascular resistance.
本文讨论了钙调节激素1,25 - 二羟胆钙化醇[1,25(OH)2D3]、甲状旁腺激素（PTH）和降钙素以及相关因子如甲状旁腺高血压因子（PHF）和降钙素基因相关肽（CGRP）的血管作用及潜在的高血压作用。1,25(OH)2D3对离体血管组织具有变力性和亲钙性作用，而PTH是一种血管舒张剂。在原发性高血压患者和自发性高血压大鼠的血浆中已报道的PHF具有升压作用和亲钙性作用。降钙素无血管效应，CGRP是一种强效血管舒张剂。得出的结论是，几种负责维持Ca2+稳态的激素可调节血管Ca2+代谢和力产生能力。这些物质可能是血管功能的长期调节剂，并在决定外周血管阻力中起作用。
