Tracey R S, Wepsic H T, Alaimo J, Morris H P
Cancer Res. 1978 May;38(5):1208-12.
The variable effect of immunizations with cell-free tumor extract (TE) in a weakly antigenic (Morris hepatoma 3924a) and a highly antigenic (glioma 9L) inbred rat model system was described. Tumor enhancement was noted with the weakly antigenic tumor following either immunization with a low dose of TE admixed with Freund's adjuvant or immunization with high doses of TE. Enhancement was observed at four tumor cell challenge levels. Tumor enhancement with the highly antigenic tumor was found at only one level and was seen following immunization with intermediate doses of TE and a high tumor cell challenge. Tumor protection was only detected with the weakly antigenic tumor following immunizations with an intermediate dose of TE and challenge with a tumor cell dose 5-fold over threshold. This protection was tumor specific, as judged by an amputation and rechallenge experiment.
描述了在弱抗原性（莫里斯肝癌3924a）和强抗原性（胶质瘤9L）近交大鼠模型系统中，无细胞肿瘤提取物（TE）免疫的可变效应。在用低剂量TE与弗氏佐剂混合免疫或高剂量TE免疫后，弱抗原性肿瘤出现肿瘤增强。在四个肿瘤细胞攻击水平上观察到了增强。强抗原性肿瘤仅在一个水平上出现肿瘤增强，且在中等剂量TE免疫和高肿瘤细胞攻击后可见。仅在用中等剂量TE免疫并用超过阈值5倍的肿瘤细胞剂量攻击后，弱抗原性肿瘤才检测到肿瘤保护。通过截肢和再次攻击实验判断，这种保护具有肿瘤特异性。
