Department of Dermatology, University of Rome Tor Vergata, Rome, Italy.
J Dermatolog Treat. 2010 Nov;21(6):363-6. doi: 10.3109/09546630903386606.
Prurigo nodularis is a distressing condition characterized by the presence of multiple nodules associated with intense pruritus.
To assess the clinical efficacy and safety of betamethasone valerate 0.1% tape and a moisturizing itch-relief cream in prurigo nodularis.
Twelve patients were enrolled in this pilot comparison of betamethasone valerate 0.1% tape versus a moisturizing itch-relief cream containing feverfew. The study period was 4 weeks. Clinical evaluation was performed weekly.
Eleven subjects completed the 4 weeks of therapy. The mean visual analogue scale (VAS) for pruritus at baseline was 8.75 for both sides of the body. The side treated with betamethasone valerate 0.1% tape showed a higher clinical response (VAS score at week 4: 3.9; p < 0.005) compared with the side treated with moisturizing itch-relief cream (VAS score at week 4: 5.6; p < 0.005).
Both treatments were effective. However, the occlusive dressing enhanced the efficacy of the treatment, preventing scratching.
结节性痒疹是一种令人痛苦的疾病，其特征是存在多个结节，并伴有剧烈瘙痒。
评估 0.1%戊酸倍他米松贴剂和含小白菊的保湿止痒乳膏治疗结节性痒疹的临床疗效和安全性。
本研究比较了 0.1%戊酸倍他米松贴剂与含小白菊的保湿止痒乳膏在 12 例患者中的疗效，研究时间为 4 周。每周进行临床评估。
11 例患者完成了 4 周的治疗。基线时，双侧的平均视觉模拟量表（VAS）瘙痒评分为 8.75。与使用保湿止痒乳膏的一侧相比，使用 0.1%戊酸倍他米松贴剂的一侧具有更高的临床反应（第 4 周 VAS 评分：3.9；p < 0.005）。
两种治疗方法均有效。然而，封闭敷料增强了治疗效果，防止了搔抓。
