Plant Mycotoxin Research Unit, Western Regional Research Center, USDA-ARS, Albany, CA, USA.
Lett Appl Microbiol. 2010 Aug;51(2):177-83. doi: 10.1111/j.1472-765X.2010.02875.x. Epub 2010 May 22.
To overcome fludioxonil resistance of Penicillium expansum, a mycotoxigenic fungal pathogen causing postharvest decay in apple, by using natural phenolic chemosensitizing agents.
Fludioxonil-resistant mutants of P. expansum were co-treated with different oxidising and natural phenolic agents. Resistance was overcome by natural phenolic chemosensitizing agents targeting the oxidative stress-response pathway. These agents also augmented effectiveness of the fungicide, kresoxim-methyl. Results indicated that alkyl gallates target mitochondrial respiration and/or its antioxidation system. Fungal mitochondrial superoxide dismutase (Mn-SOD) plays a protective role against alkyl gallates.
Natural chemosensitizing agents targeting the oxidative stress-response system, such as Mn-SOD, can synergize commercial fungicides.
Redox-active compounds can serve as potent chemosensitizing agents to overcome resistance and lower effective dosages of fungicides. This can reduce costs with coincidental lowering of environmental and health risks.
通过使用天然酚类化学增敏剂来克服导致苹果采后腐烂的产毒真菌病原菌扩展青霉对氟啶酮的抗性。
用不同的氧化和天然酚类试剂对扩展青霉的氟啶酮抗性突变体进行共处理。天然酚类化学增敏剂靶向氧化应激反应途径，克服了抗性。这些试剂还增强了杀菌剂咯菌腈的效果。结果表明，烷基没食子酸酯靶向线粒体呼吸和/或其抗氧化系统。真菌线粒体超氧化物歧化酶（Mn-SOD）对烷基没食子酸酯起保护作用。
靶向氧化应激反应系统的天然化学增敏剂，如 Mn-SOD，可以与商业杀菌剂协同作用。
氧化还原活性化合物可用作有效的化学增敏剂来克服抗性并降低杀菌剂的有效剂量。这可以降低成本，同时降低环境和健康风险。
