Kim Jong H, Mahoney Noreen, Chan Kathleen L, Molyneux Russell J, May Gregory S, Campbell Bruce C
Plant Mycotoxin Research Unit, Western Regional Research Center, USDA-ARS, Albany, CA 94710, USA.
FEMS Microbiol Lett. 2008 Apr;281(1):64-72. doi: 10.1111/j.1574-6968.2008.01072.x. Epub 2008 Feb 18.
Activities of conventional antifungal agents, fludioxonil, strobilurin and antimycin A, which target the oxidative and osmotic stress response systems, were elevated by coapplication of certain benzo analogs (aldehydes and acids). Fungal tolerance to 2,3-dihydroxybenzaldehyde or 2,3-dihydroxybenzoic acid was found to rely upon mitochondrial superoxide dismutase (SOD2) or glutathione reductase (GLR1), genes regulated by the HOG1 signaling pathway, respectively. Thus, certain benzo analogs can be effective at targeting cellular oxidative stress response systems. The ability of these compounds to chemosensitize fungi for improved control with conventional antifungal agents is discussed.
针对氧化和渗透应激反应系统的传统抗真菌剂氟啶胺、嘧菌酯和抗霉素A的活性，通过与某些苯类似物（醛类和酸类）共同施用而提高。发现真菌对2,3-二羟基苯甲醛或2,3-二羟基苯甲酸的耐受性分别依赖于线粒体超氧化物歧化酶（SOD2）或谷胱甘肽还原酶（GLR1），这两个基因分别由HOG1信号通路调控。因此，某些苯类似物可有效作用于细胞氧化应激反应系统。本文讨论了这些化合物使真菌对传统抗真菌剂的控制更加敏感的能力。
